David Teplow, a Professor of Neurology (Emeritus) at University of California, Los Angeles, is an internationally recognized leader in efforts to understand and treat Alzheimer's disease. He has published more than 250 peer-reviewed articles, books, book chapters, and commentaries and served on numerous national and international scientific advisory boards. In addition to his basic science work, Dr. Teplow has had a life-long interest in general philosophy and the philosophy of science. He spent a year-long sabbatical at the University of Cambridge as a Fellow of Clare Hall and a visiting scholar in the Department of History and Philosophy of Science, where much of this book was written. This experience stimulated Dr. Teplow to create new courses at UCLA in the ethics of science, social aspects of scientific paradigm change, and the roles played by ignorance and failure in scientific progress.
'[This is] a rare and remarkable kind of book - a full-length treatment of the philosophy of science written by a highly respected scientist. The outcome is a veritable intellectual feast, including a sweep of the whole history of scientific methodology, from ancient Egypt to today's data-driven research … this book makes something of a philosophical manual for working scientists, especially those who are in the early stages of their careers. I hope that generations of students and researchers entering their scientific careers will discover this book and benefit from its abundant wisdom.' Hasok Chang, University of Cambridge (from his Foreword) 'What is science? What does it mean to 'do' science? How can science be done thoughtfully? These broad, fundamental, and challenging questions are taken on by David B. Teplow. This book also provides practical real-world advice to young scientists on such issues as formulating a worthwhile hypothesis or question; the importance of experimental approach, design, rigor, and reproducibility; avoiding bias; … I found Teplow's book to be educational, enlightening, thought-provoking, and engaging. Reading it reminded me to stop and think more deeply about the meaning and value of my own work, why I continue to 'do' science, and what I hope to accomplish.' Michael S. Wolfe, University of Kansas (from his Foreword)