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CRC Press
03 June 2020
This book brings together current information on the families that make up the kinesin superfamily of molecular motors in one comprehensive text; an ideal reference for researchers looking to make comparisons between different families, for specific information on an individual family, or simply for an overview of the kinesin superfamily. Information is clearly structured and grouped according to individual families and organised in a standardised way, allowing the reader to easily search and retrieve information on this large superfamily of molecular motors and understand how its individual members carry out a diverse variety of cellular functions.

Features:

The first book dedicated to the entire kinesin superfamily Enables a fuller understanding of this family of proteins, which is becoming an increasing focus of research due to its involvement in diseases such as cancer, neuropathies and ciliopathies Written in a manner accessible to a range of researchers in the life and medical sciences, including biophysicists, biochemists and medical researchers. Chapter 4 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here.

Chapter 11 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here.
Edited by:   Claire T. Friel (School of Life Sciences University of Nottingham Medical School Queen's Medical Centre Nottingham UK)
Imprint:   CRC Press
Country of Publication:   United Kingdom
Dimensions:   Height: 235mm,  Width: 156mm, 
Weight:   503g
ISBN:   9781138589568
ISBN 10:   113858956X
Pages:   172
Publication Date:   03 June 2020
Audience:   College/higher education ,  Primary
Format:   Hardback
Publisher's Status:   Active
Contents Acknowledgements....................................................................................................ix Editor bio...................................................................................................................xi List of Contributors................................................................................................. xiii Chapter 1 Introduction to the Kinesin Superfamily..............................................1 Hannah R. Belsham and Claire T. Friel Chapter 2 The Kinesin-1 Family: Long-Range Transporters.............................. 15 David D. Hackney and Alison E. Twelvetrees Chapter 3 The Kinesin-2 Family: Transporters................................................... 33 William O. Hancock Chapter 4 The Kinesin-3 Family: Long-Distance Transporters.......................... 41 Nida Siddiqui and Anne Straube Chapter 5 The Kinesin-4 Family......................................................................... 55 Claire T. Friel Chapter 6 The Kinesin-5 Family: Transporters and Creators.............................65 Mary Popov, Alina Goldstein-Levitin and Larisa Gheber Chapter 7 The Kinesin-6 Family.........................................................................83 Claire T. Friel Chapter 8 The Kinesin-8 Family.........................................................................87 Tianyang Liu, Alejandro Pena, Fiona Shilliday, and Carolyn A. Moores Chapter 9 The Kinesin-13 Family: Specialist Destroyers.................................. 101 Julie P. Welburn and Claire T. Friel Chapter 10 The Kinesin-14 Family...................................................................... 115 Marcus Braun, Stefan Diez and Zdenek Lansky Chapter 11 The Kinesin-15 Family...................................................................... 135 Hauke Drechsler, Jaspreet Singh Grewal and Andrew D. McAinsh Chapter 12 The Kinesin-16 Family...................................................................... 155 Hanan M. Alghamdi and Claire T. Friel Chapter 13 Other Kinesin Families..................................................................... 161 Claire T. Friel Chapter 14 Summary and Future Perspectives.................................................... 165 Claire T. Friel Index....................................................................................................................... 167

Claire T. Friel earned a BSc in Biochemistry from the University of Glasgow, UK, and carried out her PhD work on protein folding kinetics in the laboratory of Sheena Radford at the University of Leeds, UK. In 2006, she joined the group of Jonathon Howard at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. There, she solved the ATP turnover cycle of the microtubule depolymerising Kinesin-13, MCAK, and developed an interest in the kinesin superfamily of molecular motors. Since 2011, Claire has held the position of Assistant Professor at the University of Nottingham, UK. The research goals of the Friel lab are to understand the relationship between the kinesin motor domain sequence and the many functional properties of the kinesin superfamily and to understand the molecular mechanisms of proteins that regulate microtubule dynamics.

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