The Cryptorchid Testis

Thomas O. Abney, Brooks A. Keel

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English

CRC Press
02 December 2019

Current knowledge concerning both morphological and functional cryptorchid-related alterations in the various testicular compartments is summarized in this valuable new publication. Damage to the germinal epithelium and resulting infertility in both humans and experimental animals as well as the degree of damage to the different stages of germ cell development is discussed. In addition, information concerning hormonal therapy and orchidopexy to reverse cryptorchid-related damage is provided. Morphological alterations in Sertoli and Leydig cells is discussed in terms of cellular hypertrophy and hyperplasia, alterations in organelle number and characteristics as well as changes in cell-cell junctional complexes. Changes in Sertoli cell and Leydig cell function, including gonadotropin binding, steroidogenesis and other metabolic alterations is also outlined,as well as the influence of altered testicular function on subsequent hypothalamic-pituitary changes. Vascular disruption, the potential role of paracrine substances and direct thermal damage, all of which may be responsible for the resulting detrimental changes in one or more testicular compartments, are considered.

By: Thomas O. Abney, Brooks A. Keel
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 254mm, Width: 178mm,
Weight: 453g
ISBN: 9780367450991
ISBN 10: 0367450992
Pages: 182
Publication Date: 02 December 2019
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

1. Overview of Cryptorchidism with Emphasis on the Human 2. Experimental Models of Cryptorchidism 3. Alterations in the Steroidogenic Capacity of Leydig Cells in Cryptorchid Testis 4. Testicular Regulation of Gonadotropin Microheterogeneity: Effects of Cryptorchidism 5. Alterations in Leydig Cell Morphology 6. Influence of Cryptorchidism on Leydig Cell Function 7. Changes in Sertoli Cell Structure and Functions 8. Sertoli-Leydig Cell Interactions in the Unilaterally Cryptorchid Testis 9. Cryptorchid-Induced Changes in Spermatogenesis and Fertility

Abney\, Thomas O.; Keel\, Brooks A.