The Chemical Biology of Thrombin

Roger L. Lundblad (Lundblad Biotechnology, Chapel Hill, North Carolina, USA)

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English

CRC Press
29 January 2024

Biochemistry; Molecular biology; Pharmaceutical technology

This book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis.

Key Features

Reviews the history of Thrombin (Fibrin Ferment)

Documents the relation of protein engineering and chemical modification in the study of thrombin

Summarizes the interaction of thrombin with fibrinogen and fibrin

Outlines the role of exosites in thrombin function

Describes the development of an oral inhibitor for thrombin

By: Roger L. Lundblad (Lundblad Biotechnology Chapel Hill North Carolina USA)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 526g
ISBN: 9781032203300
ISBN 10: 1032203307
Pages: 268
Publication Date: 29 January 2024
Audience: College/higher education , General/trade , Primary , ELT Advanced
Format: Paperback
Publisher's Status: Active

Roger L. Lundblad is an independent consultant based in Chapel Hill, North Carolina. He is also an adjunct professor of pathology at the University of North Carolina, Chapel Hill.