The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues.
Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues Written and edited by leaders in the field
The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.
Edited by:
Kerry Atkinson
Imprint: Wiley-Blackwell
Country of Publication: United States
Dimensions:
Height: 285mm,
Width: 224mm,
Spine: 51mm
Weight: 3.150kg
ISBN: 9781118907511
ISBN 10: 1118907515
Pages: 1048
Publication Date: 06 January 2017
Audience:
Professional and scholarly
,
Undergraduate
Format: Hardback
Publisher's Status: Active
Contributors, xxvii Editor’s Preface, xxxv Section I: An overview of mesenchymal stem cells and mesenchymal stromal cells 1 The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome, 3 Kerry Atkinson 2 The nomenclature of mesenchymal stem cells and mesenchymal stromal cells, 8 Armand Keating Section II: The isolation and ex vivo expansion of mesenchymal stromal cells 3 The isolation and expansion of mesenchymal stromal cells from bone marrow, 13 Celena F. Heazlewood 4 The biology and clinical applications of mesenchymal stromal cells derived from human gestational tissues, 24 Celena F. Heazlewood 5 Human placenta-derived mesenchymal stem/stromal cells: fetal and maternal origins and critical parameters for ex vivo expansion, 32 Rebecca A. Pelekanos and Varda S. Sardesai Section III: The cellular and molecular biology of mesenchymal stromal cells 6 Epigenetic regulation of mesenchymal stem/stromal cell growth and multipotentiality, 41 Sarah Elizabeth Hemming, Dimitrios Cakouros, and Stan Gronthos 7 Biological changes in human mesenchymal stromal cells during monolayer culture, 58 Marietta Herrmann and Jennifer J. Bara 8 The effect of three-dimensional aggregates on the biology of mesenchymal stromal cells, 75 Yijun Liu, Ang-Chen Tsai, Xuegang Yuan, and Teng Ma 9 Cell–cell signaling pathways that regulate mesenchymal stromal cell differentiation, 91 Leah Etheridge, Rebecca A. Mason, Fatima Saleh, and Paul Genever 10 Regulation of mitochondrial transport in mesenchymal stromal cells, 104 Shravani Mukherjee, Naveen K. Bhatraju, Tanveer Ahmad, and Anurag Agrawal 11 The regulation of adipogenesis from adipose-derived stem/stromal cells, 114 Lin Chen and Lei Liu 12 Modulation of osteogenic differentiation in mesenchymal stromal cells, 131 Sean Gaynard, Jessica Hayes, and Mary Murphy 13 The role of glycogen synthase kinase-3 inhibitors on bone remodeling, 148 K. Jane Escott and Patrick J. O’Shea 14 Early molecular events during in vitro chondrogenesis, 167 Tommy A. Karlsen, Rune B. Jakobsen, and Jan E. Brinchmann 15 The role of the extracellular matrix in the differentiation of mesenchymal stromal cells, 191 Peishun Shou, Qing Chen, and Yufang Shi 16 Effects of hypoxic culture on bone marrow multipotent mesenchymal stromal cells: from bench to bedside, 196 Shih-Chieh Hung 17 The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells, 208 Adisri Charoenpanich, Josephine Bodle, and Elizabeth Loboa 18 The evolving concept of mesenchymal stromal cells in regenerative medicine: from cell differentiation to secretome, 222 F.G. Teixeira, A. Pires, S.C. Serra, N. Sousa, and A.J. Salgado 19 The secretome of mesenchymal stem/stromal cells undergoing chondrogenic differentiation and those undergoing osteogenic or adipogenic differentiation, 236 Beatriz Rocha, Francisco J. Blanco, and Cristina Ruiz-Romero 20 Mesenchymal stromal cell extracellular vesicles/exosomes, 250 Ronne Wee Yeh Yeo, Ruenn Chai Lai, and Sai Kiang Lim 21 Role of tunneling nanotube crosstalk with distressed cardiomyocytes in controlling the heart repair potential of mesenchymal stromal cells, 264 Anne-Marie Rodriguez and Meriem Mahrouf-Yorgov 22 The preferential homing of mesenchymal stromal cells to sites of inflammation, 286 Catherine Sullivan 23 The role of chemokines in mesenchymal stromal cell homing to sites of inflammation, including infarcted myocardium, 314 Shan Wang and Yaojiong Wu 24 Live cell imaging and single cell tracking of’mesenchymal stromal cells in vitro, 323 James A. Cornwell, Maria Z. Gutierrez, Richard P. Harvey and Robert E. Nordon 25 The role of mesenchymal stem/stromal cells in angiogenesis, 347 Annelies Bronckaers and Ivo Lambrichts 26 The relationship between mesenchymal stromal cells and endothelial cells, 366 Seyed Mahdi Nassiri and Reza Rahbarghazi 27 The radioresistance of mesenchymal stromal cells and their potential role in the management of radiation injury, 391 Tara Sugrue, Irene Calvo-Asensio, and Rhodri Ceredig 28 The implications of multipotent mesenchymal stromal cells in tumor biology and therapy, 415 Pratika Y. Hernanda, Maikel P. Peppelenbosch, and Qiuwei Pan 29 Mesenchymal stem/stromal cell therapy: mechanism of action and host response, 426 Aideen Ryan, Mary Murphy, and Frank Barry 30 The differences between mesenchymal stromal cells and fibroblasts, 441 Luigi Balducci, Sharon Natasha Cox, and Giulio Alessandri 31 Derivation of mesenchymal stem/stromal cells from induced pluripotent stem cells, 456 Rebecca A. Pelekanos 32 The role of mesenchymal stem cells in hematopoiesis, 467 Jean-Pierre Levesque, Rebecca N. Jacobsen, and Ingrid G. Winkler 33 The modulatory effects of mesenchymal stromal cells onthe innate immune system, 481 Ko-Jiunn Liu, Men-Luh Yen, Li-Tzu Wang, and B. Linju Yen 34 The modulatory effects of mesenchymal stromal cells on the adaptive immune system, 490 B. Linju Yen, Ko-Jiunn Liu, Men-Luh Yen, and Huey-Kang Sytwu 35 The role of mesenchymal stromal cells in the repair of acute organ injury, 496 A.A. Temnov, A.V. Vagabov, A.N. Sklifas, V.I. Novoselov, and Y.A. Belyi 36 The use of mesenchymal stromal cells in the treatment of diseases of the cornea, 524 Damien G. Harkin, Allison J. Sutherland, Laura J. Bray, Leanne Foyn, Fiona J. Li, and Brendan G. Cronin 37 The role of paracrine factors secreted by mesenchymal stromal cells in acute tissue injury, 544 Ying Wang, Tania Velletri, Chunxing Zheng, and Yufang Shi 38 Treatment of lung disease by mesenchymal stromal cell extracellular vesicles, 553 Antoine Monsel, Ying-gang Zhu, Varun Gudapati, and Jae-Woo Lee 39 Evaluating mesenchymal stem/stromal cells for treatment of asthma and allergic rhinitis, 573 Tatyana Gavrilova, Saritha Kartan, Lauren S. Sherman, Oleta A. Sandiford, and Pranela Rameshwar 40 Stem cell therapies for Huntington’s disease, 581 A.T. Crane, J. Rossignol, and G. L. Dunbar Section IV: The role of bioengineering in the therapeutic applications of mesenchymal stromal cells 41 Endometrial mesenchymal stromal cell and tissue engineering for pelvic organ prolapse repair, 601 Shanti Gurung, Jerome A. Werkmeister, and Caroline E. Gargett 42 Closed automated large-scale bioreactors for manufacturing mesenchymal stromal cells for clinical use, 616 Kerry Atkinson, Nicholas Timmins, G. Kiel, Celena Heazlewood, Michael Doran, and Gary Brooke Section V: GMP manufacturing of mesenchymal stromal cells for clinical use 43 Current good manufacturing practice for the isolation and ex vivo expansion of mesenchymal stromal cells derived from term human placenta for use in clinical trials, 621 Kerry Atkinson, Dahlia Khalil, Celena Heazlewood, and Nina Ilic 44 A comparison of high-tier regulatory documents pertaining to biologic drugs including mesenchymal stromal cells in Australia, Europe, and the USA using a manual documentary analysis, 628 Nina Ilic Section VI: The therapeutic application of mesenchymal stromal cells 45 The use of mesenchymal stromal cells in acute and chronic heart disease, 647 Ariel Wolf, Wayne Balkan, and Joshua Hare 46 The role of mesenchymal stem/stromal cells in the management of critical limb ischemia, 661 P.K. Gupta, Chullikana Anoop, Balasubramanian Sudha, R Mathiazhagan, Raj Swathi Sundar, and Majumdar Anish Sen 47 The role of mesenchymal stromal cells in the management of musculoskeletal disorders, 677 Stefan Zwingenberger, Ishaq Ojodu, Maik Stiehler, and Stuart B. Goodman 48 The potential role of bone marrow mesenchymal stromal cells in the treatment of ischemic stroke, 690 Yujun Pan and Ruohan Sun 49 The role of mesenchymal stromal cells in spinal cord injury, 714 P. Jendelova, L. Machova-Urdzikova, and E. Sykova 50 The role of mesenchymal stromal cells in the treatment of ulcerative colitis and Crohn’s disease, 730 Céline Gregoire, Chantal Lechanteur, Alexandra Briquet, Etienne Baudoux, Olivier Giet, Olivier Delloye, Frédéric Baron, Edouard Louis, and Yves Beguin 51 Mesenchymal stromal cells targeting kidney disease: benefits of a combined therapeutic approach, 754 Brooke M. Huuskes and Sharon D. Ricardo 52 The biology and potential clinical applications of mesenchymal stromal cells in diseases of the lung, 770 Yuben P. Moodley, Jesse D. Armitage, and Dino B.A. Tan 53 The role of mesenchymal stromal cells in diseases of the lung, 787 Kerry Atkinson 54 Mesenchymal stromal cells for the treatment of’autoimmune diseases, 794 Christopher N. Lewis and Jacques Galipeau 55 The role of mesenchymal stromal cells in bacterial infection, 814 Sailaja Ghanta, Konstantin Tsoyi, and Mark A. Perrella 56 The use of mesenchymal stromal cells in solid organ transplantation, 825 Céline Gregoire, Alexandra Briquet, François Jouret, Chantal Lechanteur, Etienne Baudoux, Olivier Giet, Olivier Delloye, Frédéric Baron, Olivier Detry, and Yves Beguin 57 The role of mesenchymal stromal cells in allogeneic hematopoietic stem cell transplantation, 836 Kerry Atkinson 58 The role of mesenchymal stromal cells in the management of skin wounds, 841 Sung-Whan Kim 59 The role of mesenchymal stromal cells in skin wound healing, 845 Miao Teng and Hengshu Zhang Section VII: Mesenchymal stromal cells as delivery vehicles for therapeutic agents 60 The role of mesenchymal stromal cells in human brain tumors, 859 Brittany C. Parker Kerrigan, Tal Shahar, Shinji Yamashita, and Frederick F. Lang 61 Mesenchymal stromal cells as gene delivery vehicles to treat nonmalignant diseases, 873 Julie R. Beegle, Jan A. Nolta, and Fernando A. Fierro 62 Gene therapy for cancer using mesenchymal stromal cells, 892 Ryosuke Uchibori and Keiya Ozawa Section VIII: The present and the future 63 Breaking news, 901 Kerry Atkinson 64 Reconciling the stem cell and paracrine paradigms of mesenchymal stem cell function, 912 Siddaraju V. Boregowda and Donald G. Phinney Glossary, 927 Index, 949
Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.
