Tangled Up

The History and Science of Alzheimer's Disease

Michael Hornberger (University of East Anglia)

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Hardback

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English

Canbury
24 April 2025

Care of the elderly; History of medicine; Home nursing & caring

The only comprehensive guide to the history and science of Alzheimer’s disease

With vivid examples, dementia expert Michael Hornberger takes you on a whistle-stop tour of every aspect of Alzheimer's disease, from its origins to modern diagnosis and treatment.

Professor Hornberger shows how you can protect yourself and your family from developing the disease. His book explains:

What causes Alzheimer’s disease Why Alzheimer’s often affects memory first The role of genetics in raising and lowering risk for the disease The chances you will inherit Alzheimer’s from your parents The practical steps you can take to reduce your risk of getting dementia

Alzheimer’s disease accounts for around 70% of all people with dementia and its incidence is growing.

Prof Hornberger, a neuroscientist who has researched Alzheimer’s for decades, delves into this most common form of dementia by looking at the very first patient, Auguste Deter, who was diagnosed with ‘Alzheimer’s’. Mrs Deter was interviewed by a pioneering German doctor, Alois Alzheimer. She could remember her wedding but not her husband's name or where they lived.

Generally, old memories thrive in most people with Alzheimer's disease, while newer ones are harder to remember. But, as this guide explains, some lesser-known Alzheimer's variants, such as Posterior Cortical Atrophy, do not start with memory loss.

Prof Hornberger explains the role that inherited genes play in transmitting Alzheimer's, including the important difference between risk genes and familial Alzheimer’s disease genes – which make developing the disease a near certainty.

Finally, the book looks at new ‘biomarkers’ and blood tests to detect, diagnose and monitor Alzheimer’s, and which new treatments are emerging.

Prof Hornberger warns that popularly touted techniques to prevent Alzheimer's may not be worth your time or money. Instead, he sets out the steps you can take to protect yourself from this debilitating degenerative disease.

Reviews

‘A fascinating journey, both historically and scientifically, from the first recorded case of Alzheimer’s disease through to modern therapies. This book is essential reading for anyone wanting to understand the real science behind what causes Alzheimer’s disease and how best to prevent it.’ – John O’Brien, Professor of Old Age Psychiatry, University of Cambridge

‘This is such a clear and interesting book, which takes away the fear from something to which we are all at risk. It is high time we knew more, and this is just the place to start.’ – Professor Tom Shakespeare, Professor of Disability Research, London School of Hygiene and Tropical Medicine

‘It expertly balances deep scientific insights with engaging storytelling... As we enter an era of hope in our battle against this devastating disease, Tangled Up is an invaluable resource for the curious reader, be they caregiver, scientist or medical professional.’ – Karen Duff, Centre Director, UK Dementia Research Institute, University College London

About the author

Michael Hornberger is Professor of Applied Dementia Research at the University of East Anglia in the UK. He regularly meets patients with Alzheimer’s disease as part of his research aimed at improving diagnosis, disease tracking and symptom management.

Buy the book and carry on reading

By: Michael Hornberger (University of East Anglia)
Imprint: Canbury
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 153mm, Spine: 22mm
Weight: 300g
ISBN: 9781914487637
ISBN 10: 191448763X
Pages: 252
Publication Date: 24 April 2025
Audience: General/trade , Professional and scholarly , Adult education , ELT Advanced , Undergraduate
Format: Hardback
Publisher's Status: Active

TABLE OF CONTENTS Preface Prologue Part I – Alois & Auguste (and a bit of Oskar) Chapter 1 – Dr Hoffmann’s vision Chapter 2 – Mrs Deter Chapter 3 – Alois Alzheimer Chapter 4 – Munich via Heidelberg Chapter 5 – 1906 Chapter 6 – The Tübingen aftermath Chapter 7 – Fischer’s disease Chapter 8 – Alzheimer’s legacy Part I – Summary Part II – Memory and Space Chapter 9 – ‘You are not my type’ Chapter 10 – The art of memory Chapter 11 – ‘Secret’ memory techniques Chapter 12 – ‘Attention!’” Chapter 13 – ‘Enter the seahorse’ Chapter 14 – Encoding, storage, retrieval Chapter 15 – ‘It’s all about access’ Chapter 16 – The imaginary Mrs A Chapter 17 – Spatial Disorientation Chapter 18 – ‘Lost in space’ Part II – Summary Part III – Amyloid and Tau Chapter 19 – Glorious proteins Chapter 20 – Amyloid Chapter 21 – Beta-amyloid formation Chapter 22 – ‘Location, location, location… and timing’ Chapter 23 – Tau Chapter 24 – ‘Who ordered all the phosphate?’ Chapter 25 – Tau ‘infection’ Chapter 26 – Amyloid versus Tau Chapter 27 – The ‘emergence’ of the disease Chapter 28 – Biomarker technology Chapter 29 – Amyloid treatment approaches Decreasing beta-amyloid production Prevention of beta-amyloid accumulation Increase of beta-amyloid removal Chapter 30 – Tau treatment approaches Decrease of overall tau Decrease of tau phosphorylation Decrease phosphorylated tau accumulation Increase phosphorylated tau removal Chapter 31 – Why have drug trials failed so far? Phase I Phase II Phase III Part III – Summary Part IV – Genetics and lifestyle Chapter 32 – Genetics 101 Chapter 33 – Familial Alzheimer’s disease APP PSEN MAPT Chapter 34 – ‘Modifiable’ risk genes APOE TREM2 Chapter 35 – A word on genetic testing Chapter 36 – Non-modifiable lifestyle factors Age Education Hearing loss Chapter 37 – Modifiable lifestyle factors Diabetes, hypertension and obesity Physical activity Diet and nutrition Sleep Other modifiable lifestyle risk factors Part IV – Summary Part V – Rarer forms of Alzheimer’s disease Chapter 38 – Frontal variant Alzheimer’s disease Chapter 39 – Posterior Cortical Atrophy Chapter 40 – Logopenic variant primary progressive aphasia Chapter 41 – Corticobasal syndrome Chapter 42 – A final word on the rarer forms of Alzheimer’s disease Part V – Summary Epilogue Further country specific links (English language) Index

Michael Hornberger is Professor of Applied Dementia Research and Associate Dean of Innovation at Norwich Medical School at the University of East Anglia in the UK. He regularly meets patients with Alzheimer’s disease as part of his research aimed at improving diagnosis, disease tracking and symptom management. Michael is originally from Germany and studied at the universities of Osnabruck and Vienna. He gravitated to England where he did his PhD at University College London before working at Cambridge University. He spent six years in Sydney, Australia, before returning to Cambridge. He finally arrived at UEA in November 2015. In his spare time, he listens to jazz.

Reviews for Tangled Up: The History and Science of Alzheimer's Disease

'A fascinating journey, both historically and scientifically, from the first recorded case of Alzheimer’s disease through to modern therapies. This book is essential reading for anyone wanting to understand the real science behind what causes Alzheimer’s disease, and how best to prevent it.' – John O'Brien, Professor of Old Age Psychiatry, University of Cambridge 'This is such a clear and interesting book, which takes away the fear from something to which we are all at risk. It is high time we knew more, and this is just the place to start.' – Professor Tom Shakespeare, Professor of Disability Research, London School of Hygiene and Tropical Medicine 'An enlightening exploration of complex concepts, approached with humour and warmth, and made accessible to all. The book expertly balances deep scientific insights with engaging storytelling, providing readers with a detailed understanding of Alzheimer’s disease from its historical beginnings, to our current understanding of its effects on brain biology and memory. As we enter an era of hope in our battle against this devastating disease, Tangled Up is an invaluable resource for the curious reader, be they caregiver, scientist or medical professional.' – Karen Duff, Centre Director, UK Dementia Research Institute at University College London