Systems Biology of Cell Signaling

Recurring Themes and Quantitative Models

James Ferrell

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English

CRC Press
28 September 2021

Cellular biology (cytology); Automatic control engineering; Environmental science, engineering & technology; Systems analysis & design

How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes.

Key Features:

Full-color illustration program with diagrams to help illuminate the concepts Enables the reader to apply modeling and theory to the biological processes Further Reading for each chapter High-quality figures available for instructors to download

By: James Ferrell
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 280mm, Width: 210mm,
Weight: 1.002kg
ISBN: 9780367643836
ISBN 10: 0367643839
Pages: 266
Publication Date: 28 September 2021
Audience: College/higher education , Primary , A / AS level
Format: Hardback
Publisher's Status: Active

James E. Ferrell, Jr., MD, PhD is Professor of Chemical and Systems Biology and Professor of Biochemistry at Stanford. His work, which makes use of quantitative experimental approaches, modeling and theory, looks to understand the design principles of biochemical switches, timers, and oscillators, especially those that control the cell cycle.