Frederick B Marcus graduated from MIT with high honours in physics, and obtained a doctorate in plasma physics from the University of Oxford, followed by a post-doc at Oxford and the UKAEA Culham Laboratory on the Superconducting Levitron. At the Oak Ridge National Lab, a detailed design was produced of a potential Tokamak fusion reactor, after which the author worked at General Atomics on the Doublet III experiment. At the Swiss Federal Institute of Technology at Lausanne, he was responsible for the physics and engineering design and initial construction phase of TCV. At the European Commission fusion project JET at Culham, he developed and operated neutron diagnostics and was scientific secretary for designing and carrying out the high power deuterium-tritium fusion experiments. After JET, he supervised European projects on systems approaches to computational biology.