Structure and Function of Glutathione S-Transferases

Kenneth D. Tew (University of South Carolina, Charleston, USA), Cecil B. Pickett, Timothy J. Mantle , Bengt Mannervik (University of Uppsala, Sweden)

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English

CRC Press Inc
26 August 1993

Infectious & contagious diseases; Enzymology

Structure and Function of Glutathione S-Transferases provides some of the latest information available on a variety of structural and functional components of glutathione S-transferases, a family of isozymes involved in many endogenous and exogenous functions in cells. Molecular studies presented in the book focus on the regulation of these enzymes and identify important response elements. X-ray crystallographic structures show detailed information on the structural aspects of these proteins. Metabolism of a number of carcinogens and drugs is covered in detail, and the role that these enzymes play in governing drug resistance at the preclinical and clinical levels is discussed. The book will be excellent for biochemists, pharmacologists, oncologists, experimental therapeutic specialists, and others interested in glutathione S-transferases.

By: Kenneth D. Tew (University of South Carolina Charleston USA), Cecil B. Pickett, Timothy J. Mantle, Bengt Mannervik (University of Uppsala, Sweden), Timothy J. Mantle
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions: Height: 234mm, Width: 156mm, Spine: 235mm
Weight: 725g
ISBN: 9780849345821
ISBN 10: 0849345820
Pages: 336
Publication Date: 26 August 1993
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Functions of GST. Molecular Enzymology. Gene Expression. Resistance to Drugs and Oxidative Stress.

Kenneth D. Tew, Cecil B. Pickett; Timothy J. Mantle; Bengt Mannervik