Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocolitica...

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Bastian Bräuning

Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocolitica

Bastian Bräuning

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English

Springer Nature Switzerland AG
09 October 2019

Analytical chemistry; Proteins; Bacteriology (non-medical); Biochemical engineering

Series: Springer Theses

This book discusses the decoding of the lytic mechanism of an α-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families. Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Bräuning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts.

By: Bastian Bräuning
Imprint: Springer Nature Switzerland AG
Country of Publication: Switzerland
Edition: 2019 ed.
Dimensions: Height: 235mm, Width: 155mm,
Weight: 454g
ISBN: 9783030294380
ISBN 10: 3030294382
Series: Springer Theses
Pages: 86
Publication Date: 09 October 2019
Audience: Professional and scholarly , College/higher education , Undergraduate , Further / Higher Education
Format: Hardback
Publisher's Status: Active

Bastian Bräuning completed his undergraduate and postgraduate education at the LMU Munich and the Weizmann Institute of Science, Israel. He subsequently pursued doctoral training with Prof. Michael Groll at the TUM Munich, where he mastered biochemical and structural techniques for the analysis of membrane protein complexes. Currently, he is a postdoctoral fellow in Prof. Brenda Schulman’s group at the Max Planck Institute of Biochemistry, where his focus continues to be on challenging membrane protein targets and their regulation.