Solid-Phase Synthesis

A Practical Guide

Fernando Albericio, Fernando Albericio, R. B. Merrifield

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English

CRC Press Inc
28 April 2000

Polymer chemistry; Solid state chemistry; Biochemistry

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles),

coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds

for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.

Foreword by: R. B. Merrifield
Edited by: Fernando Albericio, Fernando Albericio
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm, Spine: 279mm
Weight: 1.730kg
ISBN: 9780824703592
ISBN 10: 0824703596
Pages: 848
Publication Date: 28 April 2000
Audience: College/higher education , Professional and scholarly , Professional & Vocational , A / AS level , Further / Higher Education
Format: Hardback
Publisher's Status: Active

The solid support strategy in solid-phase synthesis; amino acids -alpha-amino protecting groups; side-chain protecting groups; solid supports for the synthesis of peptides and small molecules; coupling methods - solid-phase formation of amide and ester bonds; homodetic cyclic peptides; disulfide formation in synthetic peptides and proteins -the state of the art; solid-phase convergent approaches to the synthesis of native peptides and proteins; preparation of glyco-, phospho-, and sulfopeptides; oligonucleotide synthesis; synthesis of oligonucleotide-peptide conjugates and nucleopeptides; the chemistry of peptide nucleic acids; solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics; instrumentation; the purification of synthetic peptides; analysis of synthetic peptides; the chromatographic analysis of combinational arrays - parallel HPLC and HPLC-MS.

Steven A. Kates, Fernando Albericio

Reviews for Solid-Phase Synthesis: A Practical Guide

""Prepublication praise for Solid-Phase Synthesis. . . Both Fernando Albericio and Steven Kates, as well as most of the authors of individual chapters, are well known to members of the synthetic peptide community and the information they provide can be considered authoritative and reliable. . .. While writing this piece I had occasion to look in the manuscript for answers to two specific questions and readily found both. I intend to keep a copy of this book on my desk for ready reference and I can recommend that every peptide chemist and many classical organic chemists do the same."" ---from the Foreword by R. B. Merrifield, The Rockefeller University, New York, N.Y.