Small Molecules in Oncology

Uwe M. Martens

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Hardback

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English

Springer-Verlag Berlin and Heidelberg GmbH & Co. K
12 May 2014

Oncology; Haematology

Series: Recent Results in Cancer Research

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Edited by: Uwe M. Martens
Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Country of Publication: Germany
Edition: 2nd ed. 2014
Volume: 201
Dimensions: Height: 235mm, Width: 155mm, Spine: 24mm
Weight: 7.745kg
ISBN: 9783642544897
ISBN 10: 3642544894
Series: Recent Results in Cancer Research
Pages: 417
Publication Date: 12 May 2014
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Reviews for Small Molecules in Oncology

The book is recommended for healthcare professionals, scientists, and students in medical and scientific fields. In 25 well-written chapters, experts in their fields of research describe in great detail 12 compounds currently in clinical use for the treatment of hematological malignancies, and 13 compounds applicable to specific mutation-containing malignancies or aimed at interfering with the microenvironment (such as angiogenesis). ... This book provides important practical information on a wide variety of novel small molecule-based treatment approaches. (George Somlo, Doody's Book Reviews, April, 2015)