Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.
With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:
Autophagy Notch Pathway P13K/PTEN Signaling in Liver Diseases Sirtuins Hepcidin and Iron Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis Oxidative Stress and Signaling in the Liver.
Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.
Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.
List of Contributors, vii 1 Hepatocytes 1 Jean-François Dufour and Joachim C. Mertens 2 Signaling pathways in biliary epithelial cells 15 M. Fatima Leite, Mateus T. Guerra, Viviane A. Andrade and Michael H. Nathanson 3 Stellate cells 34 Alessandra Caligiuri and Fabio Marra 4 Kupffer cells 61 Amirali Kiyani and Ekihiro Seki 5 Hepatic sinusoidal endothelial cells 73 Moira B. Hilscher Robert C. Huebert and Vijay H. Shah 6 Extracellular matrix 85 Scott L. Friedman 7 Platelets: a new cell type in liver physiology 97 Mickaël Lesurtel and Pierre]Alain Clavien 8 Immune cell communication in liver disease and liver regeneration 110 R. Harminder Boghal, B.F. Stephenson and Simon C. Afford 9 Extracellular vesicle RNA in liver disease 130 Tushar Patel and Hiroaki Haga 10 Endoplasmic reticulum stress in nonalcoholic fatty liver disease 139 Fabienne Foufelle and Pascal Ferré 11 Autophagy 151 Hao Zhang, Bilon Khambu and Xiao]Ming Yin 12 CXC chemokine receptor signaling in liver repair and regeneration 166 Gregory C. Wilson, Christopher M. Freeman, Hiroyuki Nojima and Alex B. Lentsch 13 Metabolic regulation of liver regeneration 174 Jiansheng Huang and David A. Rudnick 14 TNF signaling 186 Amrit Mann, Mark J. Czaja and Jörn M. Schattenberg 15 Fas/FasL 203 Maria Eugenia Guicciardi and Gregory J. Gores 16 Interferon signaling 214 Markus H. Heim 17 Endocannabinoid signaling in liver pathologies 226 Bostjan Humar and Nasser Semmo 18 The WNT/β]catenin pathway 240 Satdarshan P. Singh Monga 19 Hedgehog signaling in the liver 262 Mariana V. Machado and Anna Mae Diehl 20 Notch pathway 275 Sonja Rothweiler and David Semela 21 PI3K/PTEN signaling in liver diseases 287 Alfredo Fort, Nicolas Calo, Dorothea Portius, Lucie Bourgoin, Marion Peyrou and Michelangelo Foti 22 mTOR signaling in liver disease 314 Marion Cornu, Grégoire de Caudron de Coquereaumont and Michael N. Hall 23 LKB1/AMPK pathway in the control of hepatic energy metabolism 326 Benoit Viollet and Marc Fortes 24 NF-κB 339 Ekihiro Seki and David A. Brenner 25 c-Jun NH2]terminal kinases in liver diseases 348 Johannes Kluwe and Robert F. Schwabe 26 p53 364 Aundrietta D. Duncan, Wen]Wei Tsai and Michelle Craig Barton 27 Sirtuins 374 Frank K. Huynh, Eoin McDonnell, Kristin A. Anderson and Matthew D. Hirschey 28 Bile acids and their receptors 385 Thierry Claudel and Michael Trauner 29 Hepcidin and iron 400 Chiara Vecchi and Antonello Pietrangelo 30 Gut microbiome and liver diseases 411 Herbert Tilg and Alexander R. Moschen 31 Epigenetic regulation of hepatic stellate cells and liver fibrosis 421 Jelena Mann and Derek A. Mann 32 Signaling in hepatocellular carcinoma 435 Adam Pennycuick and Augusto Villanueva 33 Interplay between hepatitis B virus and innate immune signaling pathways 448 Barbara Testoni, David Durantel and Fabien Zoulim 34 Signaling of hepatitis C virus 459 Joachim Lupberger, Nicolaas Van Renne and Thomas F. Baumert 35 Oxidative stress and signaling in the liver 469 Mitchell R. McGill, Yuchao Xie and Hartmut Jaeschke Index 000
Professor Jean-François Dufour, MD, PhD, Chief, Department of Clinical Pharmacology, University Clinic Visceral Surgery and Medicine, Bern, Switzerland. Professor Dufour is on the governing board of the European Association for the Study of the Liver (EASL). He also serves as Associate Editor for the Wiley journal Liver International and is on the editorial board for the following journals: Journal of Hepatology; Clinical Science; World Journal of Gastroenterology Professor Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, Switzerland. Professor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland. His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award.
