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Signaling by Toll-Like Receptors

Gregory W. Konat



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CRC Press
07 October 2019
The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.
Edited by:   Gregory W. Konat
Imprint:   CRC Press
Country of Publication:   United Kingdom
Dimensions:   Height: 234mm,  Width: 156mm, 
Weight:   408g
ISBN:   9780367387181
ISBN 10:   0367387182
Pages:   224
Publication Date:   07 October 2019
Audience:   College/higher education ,  Further / Higher Education
Format:   Paperback
Publisher's Status:   Active
Assessing the Response of Cells to TLR Stimulation. TLR Ligands in Experimental Settings: Their Purity and Specificity. Analysis of TLR Expression, Regulation, and Signaling. Intracellular Trafficking of Toll-Like Receptors. The Role of Small RhoGTPases in TLR Signaling. Use of Engineered -Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors. Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling. Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling. Role of Toll-Like Receptor Signaling in Central Nervous System Infections. The Influence of Injury on Toll-Like Receptor Responses. Index.

Gregory W. Konat

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