All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling.
Key selling features:
Focuses on smooth muscles of different types
Describes ion channel signaling mechanisms
Reviews calcium and receptor signaling
Includes novel, cutting-edge methodologies
Summarizes studies of mice with genetically encoding sensors in smooth muscle
Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 4.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498774222_oachapter9.pdf
Series Preface Preface Editors Contributors Chapter 1 Elucidation of Vasopressin Signal Transduction Pathways in Vascular Smooth Muscle Kenneth L. Byron and Lyubov I. Brueggemann Chapter 2 Investigating Chloride Channels in Smooth Muscle Henry R. Askew Page and Iain A. Greenwood Chapter 3 Methods for the Isolation of and Study of Ca2+ Signaling in Arteriolar Smooth Muscle Cells William F. Jackson Chapter 4 Ion Channel Trafficking in Arterial Smooth Muscle Cells and Functional Significance M. Dennis Leo and Jonathan H. Jaggar Chapter 5 Total Internal Reflection Fluorescence Microscopy in Vascular Smooth Muscle Madeline Nieves-Cintrón, Sendoa Tajada, L. Fernando Santana, and Manuel F. Navedo Chapter 6 T-Type Ca2+ Channels in Vascular Smooth Muscle: Properties, Regulation, and Function Osama F. Harraz, Ahmed M. Hashad, and Donald G. Welsh Chapter 7 Calcium Sensitization in Smooth Muscle Involving Regulation of Myosin Light Chain Phosphatase Activity Justin A. MacDonald, Michael P. Walsh, and William C. Cole Chapter 8 Approaches for Investigating the Functional Significance of Transient Receptor Potential Cation Channels in Smooth Muscle Cells Harry A. T. Pritchard, Paulo W. Pires, and Scott Earley Chapter 9 Mitochondria Structure and Position in the Local Control of Calcium Signals in Smooth Muscle Cells John G. McCarron, Christopher Saunter, Calum Wilson, John M. Girkin, and Susan Chalmers Chapter 10 ORAI Channels in Vascular Smooth Muscle Maxime Guéguinou, Xuexin Zhang, Trayambak Pathak, Scott Emrich, Ryan Yoast, and Mohamed Trebak Chapter 11 G Protein-Coupled Receptors in Airway Smooth Muscle Function and Obstructive Lung Disease Tonio Pera and Raymond B. Penn Chapter 12 Brain-Derived Neurotrophic Factor in Airway Smooth Muscle: Contributions to Asthma Michael Thompson, Rodney Britt Jr, Anne Roesler, Katelyn Cummings, Christina M. Pabelick, and Y. S. Prakash Chapter 13 Antibody-Based Approaches for Protein Analysis of Smooth Muscles Brian A. Perrino and Yeming Xie Chapter 14 Role of Ion Channels in Urinary Bladder Smooth Muscle Function Georgi V. Petkov Chapter 15 Methods for Investigating the Regulation of Smooth Muscle Excitability by Interstitial Cells Bernard T. Drumm and Kenton M. Sanders Chapter 16 Electrical Pacemaking in Lymphatic Vessels Scott D. Zawieja, Jorge A. Castorena-Gonzalez, Kim H. T. To, Peichun Gui, Timothy Domeier, and Michael J. Davis Chapter 17 NADPH Oxidase, Redox Signaling, and Vascular Smooth Muscle Function Daniel S. de Jesus, Eugenia Cifuentes-Pagano, Sanghamitra Sahoo, and Patrick J. Pagano Index
Mohamed Trebak is Professor of Cellular and Molecular Physiology at the Penn State Hershey College of Medicine. Scott Earley is Associate Professor of Pharmacology at the University of Nevada Reno.
