Sex Determination, Differentiation and Intersexuality in Placental Mammals

R. H. F. Hunter (University of Montreal and University of Edinburgh)

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English

Cambridge University Press
14 April 2011

Genetics (non-medical); Animal reproduction; Zoology: Mammals

How do males become male and females become female? And what are the consequences if the decision is not incisive? Drawing upon interests in animal genetics and molecular biology, the author endeavours to answer these difficult yet fascinating questions. Originally published in 1995, this book describes the genetic determination of sex and examines how sexual organs are differentiated. Using examples of intersexuality, chimaeras and asymmetries, the book describes the underlying molecular basis of sex determination and sexual differentiation, and focuses on the critical role of the rate of embryonic development in these vital processes. Male precocity is a recurrent theme, as is the involvement of Sertoli cells and their secretion of anti-Müllerian hormone. An invaluable book for reproductive physiologists, geneticists and developmental biologists whose interests may extend from animal science through veterinary medicine to human clinical medicine.

By: R. H. F. Hunter (University of Montreal and University of Edinburgh)
Imprint: Cambridge University Press
Country of Publication: United Kingdom
Dimensions: Height: 229mm, Width: 152mm, Spine: 19mm
Weight: 500g
ISBN: 9780521182294
ISBN 10: 0521182298
Pages: 338
Publication Date: 14 April 2011
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

1. Historical landmarks in studies of reproduction and sex determination; 2. Mechanisms of sex determination; 3. Differentiation of the gonads; 4. Differentiation of the genital duct system; 5. Anomalous sexual development in domestic species; 6. Abnormal sexual development in laboratory rodents; 7. Abnormal sexual development in man; 8. Sexual differentiation in chimaeras; 9. Asymmetries in the reproductive system and their significance; 10. Concluding thoughts and a current perspective.

Reviews for Sex Determination, Differentiation and Intersexuality in Placental Mammals

Review of the hardback: '... a pleasure to read because of Hunter's clear style ... a successful amalgamation of information from many mammalian species ... a concise and well-written summary of what is known and hypothesized about mammalian sex determination and differentiation ...' Science Review of the hardback: '... eminently suitable for the advanced students for whom it is intended and is a must for anyone involved in the field of mammalian sex differentiation.' Nature Review of the hardback: '... elegant and informative ... it fully deserves a place on the shelves of all university libraries and in departments and units with any interest in reproduction and development.' Journal of Anatomy Review of the hardback: '... a sound contribution to a fascinating, much debated, and currently widely investigated field ... a really exciting monograph.' Animal Reproduction Science ...provides a clear and factual account of the experimental evidence that has led to the present position, against a background of normal and abnormal sexual development....very readable....Hunter sets out the relevant facts and hypotheses in a perfectly detached manner, allowing readers to make up their own minds. The book is eminently suitable for the advanced students for whom it is intended, and is a must for their teachers, as well as for anyone involved in the field of mammalian sex differentiation. Ursula Mittwoch, Nature It is a pleasure to read because of Hunter's clear style and elegant exposition....I am pleased to have this concise and well-written summary of what is known and hypothesized about mammalian sex determination on my shelf as a reference. The index is excellent, and there are many important references up to 1994. Barbara R. Migeon, Science Based on the depth and sophistication of the subject matter, the book will be useful to graduate students and professionals in reproductive medicine, genetics and molecular and developmental biology. H.S. Pitkow, Choice The greatest strength of the book is the uniformity and enthusiasm provided by having a single author who is dedicated to his topic. Aline M. Davis, Trends in Endocrinology and Metabolism