Seldin and Giebisch’s The Kidney, Sixth Edition: Physiology and Pathophysiology provides a common language for nephrology researchers, fellows and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of normal renal physiology, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation.
This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise and readily accessible information. Academic, medical and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.
Edited by:
Robert J. Alpern (Dean and Ensign Professor of Medicine Yale University School of Medicine New Haven Connecticut USA),
Michael J. Caplan (C.N.H. Long Professor and Chair,
Department of Cellular and Molecular Physiology,
Yale University School of Medicine,
New Haven,
Connecticut,
USA),
Orson W. Moe (Professor of Internal Medicine and Physiology,
University of Texas Southwestern Medical Center,
Dallas,
Texas,
USA),
Susan E. Quaggin (Director,
Feinberg Cardiovascular Research Institute,
Chicago; Chief,
Division of Medicine-Nephrology,
Professor in Medicine-Nephrology,
Northwestern University,
Evanston,
IL,
USA)
Imprint: Academic Press Inc
Country of Publication: United States
Edition: 6th edition
Dimensions:
Height: 276mm,
Width: 215mm,
ISBN: 9780128153895
ISBN 10: 012815389X
Pages: 3264
Publication Date: 01 December 2025
Audience:
Professional and scholarly
,
Undergraduate
Format: Hardback
Publisher's Status: Forthcoming
Volume 1I: Epithelial and Nonepithelial Transport and Regulation1. Epithelial Cell Structure and Polarity2. Mechanisms of Ion Transport across Cell Membranes3. Renal Ion-Translocating ATPases4. Mechanisms of Water Transport Across Cell Membranes and Epithelia5. Cell Volume Control6. Solute Transport, Energy Consumption, and Production in the Kidney7. Electrophysiological Analysis of Transepithelial Transport8. Renal Ion Channels, Electrophysiology of Transport, and Channelopathies9. Microvascular Permeability and the Exchange of Water and Solutes Across Microvascular Walls10. External Balance of Electrolytes and Acids and Alkali11. Renal Cilia Structure, Function, and Physiology12. Intercellular Junctions13. Principles of Cell Signaling14. Scaffolding Proteins in Transport Regulation15. The Renin–Angiotensin System16. Neural Control of Renal Function17. Eicosanoids and Renal Function18. Extracellular Nucleotides and Renal Function19. Paracrine Regulation of Renal Function by DopamineII: Structural and Functional Organization of the Kidney20. Structural Organization of the Mammalian Kidney21. Biophysical Basis of Glomerular Filtration22. Glomerular Cell Biology23. Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion24. Renal Cortical and Medullary Microcirculations: Structure and Function25. Molecular and Cellular Mechanisms of Kidney Development26. Molecular and Cellular Mechanisms of Glomerular Capillary Development27. Postnatal Renal Development28. Renal Hyperplasia and Hypertrophy29. Stem Cells and Generation of New Cells in the Adult KidneyIII: Fluid and Electrolyte Regulation and Dysregulation30. Epithelial Na+ Channels31. Anion Channels32. Physiology and Pathophysiology of the NaCl Co-Transporters in the Kidney33. Sodium and Chloride Transport: Proximal Nephron34. Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct35. Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron36. Inherited Disorders of Renal Salt Homeostasis: Insights from Molecular Genetics Studies37. Natriuretic Hormones38. Pathophysiology of Sodium Retention and Wastage39. Physiology and Pathophysiology of Hypertension40. Physiology and Pathophysiology of Diuretic Action41. Aquaporin Water Channels in Mammalian Kidney42. Thirst and Vasopressin43. The Urine Concentrating Mechanism and Urea Transporters44. Hyponatremia45. Hypernatremic States46. Polyuria and Diabetes Insipidus47. The Molecular Biology of Renal K+ Channels48. Extrarenal Potassium Metabolism49. Regulation of K+ Excretion50. Physiopathology of Potassium DeficiencyVolume II51. Clinical Disorders of Hyperkalemia52. Control of Intracellular pH53. SLC4 Sodium-Driven Bicarbonate Transporters54. The SLC4 Anion Exchanger Gene Family55. Cellular Mechanisms of Renal Tubular Acidification56. Chemoreceptors, Breathing and pH57. Renal Ammonium Ion Production and Excretion58. Clinical Syndromes of Metabolic Alkalosis59. Clinical Syndromes of Metabolic Acidosis60. Respiratory Acid–Base Disorders61. Mechanisms and Disorders of Magnesium Metabolism62. Calcium Channels63. The Calcium-Sensing Receptor64. Renal Calcium Metabolism65. The Hormonal Regulation of Calcium Metabolism66. Disorders of Calcium Metabolism67. Pathogenesis and Treatment of Nephrolithiasis68. Proximal Tubular Handling of Phosphate69. Clinical Disturbances of Phosphate Homeostasis70. Glucose Reabsorption in The Kidney71. Kidney Transport of Amino Acids and Oligopeptides, and Aminoacidurias72. Organic Anion and Cation Transporters in Renal Elimination of Drugs73. Renal Filtration, Transport, and Metabolism of Albumin and AlbuminuriaIV: Pathophysiology of Renal Disease74. Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid–Base Disorders75. Biomarkers for Assessment of Renal Function During Acute Kidney Injury76. Pathophysiology of Acute Kidney Injury77. Ischemic Renal Disease78. Pathophysiology and Pathogenesis of Diabetic Nephropathy79. Renal Failure in Cirrhosis80. Autosomal Dominant Polycystic Kidney Disease81. Renal Physiology and Disease in Pregnancy82. Immune and Inflammatory Glomerular Diseases83. Immunologic Mechanisms of Vasculitis84. Genetic Abnormalities in Glomerular Function85. Cellular Mechanisms of Drug Nephrotoxicity86. Role of Glomerular Mechanical Stress in the Pathogenesis of Chronic Kidney Disease87. Role of Proteinuria in the Progression of Renal Disease88. The Inflammatory Response to Ischemic Acute Renal Injury89. Catalytic (Labile) Iron in Kidney Disease90. Chronic Kidney Disease: Pathophysiology and the Influence of Dietary Protein91. Management of Calcium and Bone Disease in Renal Patients92. Hematopoiesis and the Kidney93. Individualizing the Dialysate to Address Electrolyte Disturbances in the Dialysis Patient94. Homeostasis of Solute and Water by the Transplanted Kidney95. Renal Disposition of Drugs and Translation to Dosing Strategies
Dr. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in Internal Medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the medical school. He is now Dean of Yale School of Medicine and Ensign Professor. Dr. Caplan studies epithelial cell biology and physiology. His work focuses on the trafficking and regulation of renal ion transport proteins. His group also studies the signaling pathways involved in Autosomal Dominant Polycystic Kidney Disease. He received his MD and PhD degrees from Yale University, having pursued his dissertation work in the Department of Cell Biology under the guidance of Drs. James D. Jamieson and George E. Palade. Following postdoctoral work in the Department of Cellular and Molecular Physiology at Yale, Caplan joined that department as a faculty member. He is currently the C.N.H. Long Professor and Chair of Yale University School of Medicine’s Department of Cellular and Molecular Physiology. Dr. Moe received his medical degree from the University of Toronto where he also did his internal medicine residency and clinical nephrology fellowship. Orson Moe moved to the University of Texas Southwestern Medical Center for research training in renal physiology. He is currently Professor of Internal Medicine and Physiology and is a member of the Nephrology Division at the University of Texas Southwestern Medical Center in Dallas. He is also the Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and holds the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. Orson Moe conducts both basic science and patient-oriented research on renal physiology and metabolism, and epithelial biology. Susan E. Quaggin, MD, FASN, is a graduate of the University of Toronto where she completed her residency and served as chief medical resident for the University’s St. Michael’s Hospital. She completed her nephrology fellowship at the University of Toronto and Yale University, where she also completed research and post-doctoral training. Dr. Quaggin also trained in the developmental biology program at the University of Toronto's Samuel Lunenfeld Research Institute. Dr. Quaggin also now serves as Editor for Current Opinion in Nephrology & Hypertension and The Kidney, and as an Editorial Board Member for JCI, Disease Models and Mechanisms, and Kidney International. Currently the Charles Horace Mayo professor of medicine at Northwestern University and a Finnish Distinguished Professor (2012-2017), Dr. Quaggin’s awards and honors include the International Society of Nephrology (ISN) Alfred Newton Richards Award for Basic Science, (2013); a Kidney Foundation of Canada Medal for Research Excellence, (2009); American Heart Association, Hypertension Council Donald Seldin Lecture and Award, (2012); Princesses’ Lectureship at the Victor Chang Cardiovascular Research Institute, (2013); a W. Berliner Lectureship at Yale University, (2015); a Ruth Abrahmson Visiting Lectureship, (2015); a Josh Thurman Visiting Lectureship, (2015); an Andreoli Lectureship, (2015); a Phillip A. Liverman Distinguished Lectureship, (2014); a Tisher Visiting Professor of Nephrology, (2012), a Mitch Lectureship (2016), the Shaul-Massry Visiting Professor (2017); a Gabor-Zellerman Endowed Professorship in Renal Medicine, (2009-2012); the University of Toronto's Department of Medicine Research Award, (2009) and William Goldie Prize in Internal Medicine, (2005); The Lloyd S.D. Fogler QC Award of Excellence, at Mount Sinai Hospital, (2004); Premier’s Research Excellence Award (PREA), (2003); and The Joe Doupe Canadian Society of Clinical Investigation Young Investigator Award, (2003). She served as Canada Research Chair in Vascular Biology from 2005 to 2010. She was elected to the American Society for Clinical Investigation in 2006 and the Association of American Physicians in 2013.
