Many advances have occurred in the last 5 years especially in understanding genetic susceptibility factors, the role of immune response in chronic
arthritis and the relationship between cellular processes that underlie
inflammation and tissue damage. All these are dealt with in depth in
the individual contributions. Genetics studies included illustrate how studies of HLA genes and genes controlling the autoantibody repertoire
may be involved. Environmental factors are believed to be important and studies both in humans and in experimental models on the role of viral and bacterial agents are covered. The fascinating relationship between
microbes, dysregulated immune responses and oncogenes are
also examined. Since autoimmunity is the key aspect of the
immunological response in rheumatoid arthritis, the role of antigens
is re-examined as is the part played by immune T and B cells. New areas of clinical application of basic science is well presented in this book, forexample, in examining how markers of cartilage destruction may become
important in monitoring disease activity. A chapter reviewing
possible future novel therapies is included.
Edited by:
Josef S. Smolen,
Joachim R. Kalden,
Ravinder N. Maini
Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Country of Publication: Germany
Edition: Softcover reprint of the original 1st ed. 1992
Dimensions:
Height: 235mm,
Width: 155mm,
Spine: 21mm
Weight: 639g
ISBN: 9783642761911
ISBN 10: 3642761917
Pages: 399
Publication Date: 21 December 2011
Audience:
Professional and scholarly
,
Undergraduate
Format: Paperback
Publisher's Status: Active
Is Rheumatoid Arthritis a Disappearing Disease?.- Genetics.- Genetic Factors in Rheumatoid Arthritis.- Rheumatoid Arthritis in Southeastern Europe.- Pathogenesis.- Pathogenesis of Rheumatoid Arthritis: Cellular and Cytokine Interactions.- Role of Cellular Adhesion in Rheumatoid Synovitis.- Endothelial Cells and Dendritic Cells in Rheumatoid Inflammation.- Cellular and Humoral Immune Response Against Articular Chondrocytes and Proteoglycans in Rheumatoid Arthritis.- Role and Regulation of Synovial MHC Class II Antigens in Rheumatoid Arthritis and Related Diseases.- CD5+ B Cells and Double-Negative T Cells in Rheumatoid Arthritis.- The Genetics of Rheumatoid Factors (RF): The V-gene Repertoire of RFs in Rheumatoid Arthritis as Analyzed by Hybridoma Clones.- Neutrophil Polymorphonuclear Cell Function in Rheumatoid Arthritis.- Etiologic Factors - Bacterial Antigens, Autoantigens, Viruses.- Heat-Shock Proteins and Mycobacterial Antigens.- Type-II Collagen in the Pathogenesis of Rheumatoid Arthritis.- Streptococcal Cell Wall Antigens and Rheumatoid Arthritis.- Caprine Arthritis-Encephalitis.- Oncogenes and Retroviruses in Rheumatoid Arthritis.- Are Retroviruses Involved in the Pathogenesis of Autoimmune Diseases?.- Epstein-Barr Virus and Rheumatoid Arthritis.- Antibodies to EBV-Encoded Proteins in Rheumatoid Arthritis.- Autoantibodies and Markers of Disease Activity.- The Antiperinuclear Factor (APF) and Antikeratin Antibodies (AKA) in Rheumatoid Arthritis.- Anti-RA33: A New Antinuclear Antibody in Rheumatoid Arthritis.- Acute-Phase Response and Amyloid.- Markers of Cartilage Destruction.- Therapy.- Progress in the Therapy of Rheumatoid Arthritis.- T-Cell Vaccination - A Prospect.
