Redox Regulation of Differentiation and De-differentiation

Carsten Berndt, Christopher Lillig

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English

CRC Press
18 October 2021

Medicine: general issues; Biochemistry; Developmental biology; Molecular biology; Pharmaceutical technology

Series: Oxidative Stress and Disease

Cell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine.

Key Features

Provides the first summary on this important topic

Reviews redox-dependent development of model organisms and single organs

Highlights the redox-regulated pathways important for differentiation processes

Illustrates the potential of redox medicine

Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration

Written by leading experts in the field

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Edited by: Carsten Berndt, Christopher Lillig
Imprint: CRC Press
Country of Publication: United Kingdom
Volume: 48
Dimensions: Height: 254mm, Width: 178mm,
Weight: 966g
ISBN: 9780367895662
ISBN 10: 0367895668
Series: Oxidative Stress and Disease
Pages: 380
Publication Date: 18 October 2021
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Active

Carsten Berndt is in the Department of Neurology, Heinrich-Heine-Universität Düsseldorf. He is the author or co-author of over 50 peer revidewed scholarly publications. His research has focuesd on the essential role of redox regulation in health and disease. Christopher Horst Lillig is at the Institute for Medical Biochemistry and Molecular Biology at the University of Greifswald.