Radiotracers in Drug Development

Graham Lappin, Simon Temple (Dronfield, Derbyshire, UK), Stephen Peter Newman (Pharmaceutical Profiles, Nottingham, England Pharmaceutical Profiles, Nottingham, United Kingdom) , Simon Temple (Dronfield, Derbyshire, UK)

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English

CRC Press
18 December 2019

Medicine: general issues; Pharmacology; Radiology; Biology, life sciences; Pharmaceutical technology

Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers.

The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry, positron emission tomography, gamma-scintigraphy, and radioluminography. In addition to describing how the analytical technologies work, the contributors explain how the data are interpreted and used in the drug registration process.

A unique reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this is the only comprehensive, interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.

Contributions by: Stephen Peter Newman (Pharmaceutical Profiles Nottingham England Pharmaceutical Profiles Nottingham United Kingdom), Gary Pitcairn
Edited by: Graham Lappin, Simon Temple (Dronfield, Derbyshire, UK), Simon Temple (Dronfield, Derbyshire, UK)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 453g
ISBN: 9780367453725
ISBN 10: 036745372X
Pages: 320
Publication Date: 18 December 2019
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Radiotracers and Drug Registration. Radioactivity and Radiotracers. The Study of Drug Metabolism Using Radiotracers. DNA Binding, Isotope Dilution, and Other Uses of Radiotracers. Quantitative Whole-Body Autoradiography (QWBA). Scintillation Counting. Statistics in Liquid Scintillation Counting. Instrumentation for Detection of Radioactivity. Sample Preparation for Liquid Scintillation Counting. Biomedical Accelerator Mass Spectrometry. Positron Emission Tomography. Gamma Scintigraphy and SPECT.

Graham Lappin, Simon Temple