Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects

G. Stöcklin, V.W. Pike

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English

Springer
30 June 1993

Nuclear medicine; Tomography

Series: Developments in Nuclear Medicine

Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades, about 35 are presently considered to be of major interest. This field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is designed to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceutials of today. This book should help the increasing number of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many practical guidelines and should promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here.

Edited by: G. Stöcklin, V.W. Pike
Imprint: Springer
Edition: 1993 ed.
Volume: 24
Dimensions: Height: 234mm, Width: 156mm, Spine: 12mm
Weight: 1.030kg
ISBN: 9780792323402
ISBN 10: 0792323408
Series: Developments in Nuclear Medicine
Pages: 180
Publication Date: 30 June 1993
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

1. PET radionuclide production.- Appendix 1. Sources of 18O-enriched water.- 2. Radiochemistry automation for PET.- Appendix 1. Radioactivity detectors.- Appendix 2. Selection criteria for remotely operated valves used in PET chemistry.- Appendix 3. Sources of glassy carbon vessels.- 3. Quality assurance and quality control of short-lived radiopharmaceuticals for PET.- Appendix 1. Sources of precursors and standards for QA/QC.- 4. PET radiopharmaceutical metabolism — plasma metabolite analysis.

Reviews for Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects

'I highly recommend this book to the growing number of scientists involved in the production and development of positron-emitting radiopharmaceuticals ...' European Journal of Nuclear Medicine, 21:1 'I can equivocally recommend this book as essential reading for all persons involved in PET radiopharmaceutical production. No PET radiochemist/radiopharmacist should be without a copy on their lab-bench, office desk, and restroom library.' Clinical Nuclear Medicine, 19, 1994