Through seven editions, Protocols for High-Risk Pregnancies has helped busy obstetricians keep pace with a constantly evolving field. Providing just-in-time content, its focus on protocols and guidelines helps organize medical thinking, avoid heuristic errors of omission and commission, and optimize maternal and fetal outcomes.
As with the prior six editions, the editors have once again assembled some of the world’s top obstetrical and medical experts. This seventh edition has also been expanded to include a number of new topics, including:
Protocols on opioid use, misuse and addition in pregnancy and postpartum Noninvasive prenatal diagnosis of aneuploidy Periconceptual genetic screening Expanded protocols on maternal valvular heart disease and cardiomyopathies Protocols on arboviruses, including Zika and malaria
Protocols for High-Risk Pregnancies: An Evidence-Based Approach will be an essential reference for obstetricians, medical students, general practitioners and all medical professionals who are seeking the most up-to-date information and guidance on high-risk pregnancies.
Preface ix List of Contributors xi Part 1 Concerns in Pregnancy 1 Alcohol Use in Pregnancy and Lactation 3 Ruta M. Nonacs 2 Smoking, Vaping, and Nicotine Exposure 9 John Byrne and George Saade 3 Opioid Use, Misuse, and Addiction in Pregnancy and Postpartum 15 Mishka Terplan 4 Depression 21 Kimberly Yonkers Part 2 Antenatal Testing 5 Prenatal Testing for Chromosomal Abnormalities 29 Mary E. Norton 6 Fetal Echocardiography 41 Joshua A. Copel 7 Clinical Use of Doppler 49 Henry L. Galan 8 Antepartum Testing 61 Michael P. Nageotte 9 Fetal Blood Sampling and Transfusion 69 Patricia Santiago‐Munoz 10 Preconception Genetic Screening 77 Lauren Sayres and Jeffrey A. Kuller Part 3 Maternal Disease 11 Maternal Anemia 89 Elaine Duryea 12 Hemoglobinopathies in Pregnancy 97 Bradley Sipe and Judette Louis 13 Fetal and Neonatal Alloimmune Thrombocytopenia 105 Russell Miller and Richard Berkowitz 14 Rheumatological Disorders 113 Lisa R. Sammaritano and Bonnie L. Bermas 15 Antiphospholipid Syndrome 125 Robert M. Silver 16 Inherited Thrombophilias 131 Andra H. James and Jerome J. Federspiel 17 Valvular Heart Disease in Pregnancy 141 Blake Zwerling and Afshan B. Hameed 18 Peripartum Cardiomyopathy 165 Sarah Rae Easter and Carolyn M. Zelop 19 Thromboembolism 181 Michael J. Paidas 20 Renal Disease 201 Shivani Patel 21 Obesity 209 Patrick S. Ramsey 22 Diabetes Mellitus 219 Mark B. Landon and Steven G. Gabbe 23 Thyroid Disorders 231 Elizabeth O. Buschur and Stephen F. Thung 24 Hepatitis in Pregnancy 241 Andrew Myers, Asa Oxner, John Sinnott, and Christian Brechot 25 Asthma 253 Michael Schatz 26 Epilepsy 263 Thomas McElrath 27 Chronic Hypertension 273 Michal Fishel Bartal and Baha M. Sibai 28 Cytomegalovirus, Genital Herpes, Rubella, and Toxoplasmosis 285 Kerry E. Drury and Brenna L. Hughes 29 Syphilis 293 Emily H. Adhikari 30 Vector‐Borne Diseases in Pregnancy: Zika, West Nile, and Chagas Disease 301 Karin Nielsen‐Saines and Tara Kerin 31 Influenza 317 Amanda C. Zofkie and Vanessa Rogers 32 Malaria 323 Blair J. Wylie 33 Human Immunodeficiency Virus Infection 333 Emily H. Adhikari 34 Parvovirus B19 343 Kathy C. Matthews, Emilie L. Vander Haar, and Laura E. Riley 35 Group B Streptococcus 351 Caitlin A. MacGregor, and Mara J. Dinsmoor 36 Biliary, Liver, and Pancreatic Disease 361 Vic Velanovich, Elizabeth Hoover, and Stephanie Ros Part 4 Obstetric Problems 37 Cervical Insufficiency 375 Rupsa C. Boelig and Vincenzo Berghella 38 Nausea and Vomiting 387 Jared T. Roeckner and Haywood L. Brown 39 Fetal Death and Stillbirth 397 Alexander M. Saucedo and Robert M. Silver 40 Abnormal Amniotic Fluid Volume 407 Christina M. Ackerman, Thomas R. Moore, and Heather S. Lipkind 41 Fetal Growth Restriction 421 Jodi S. Dashe and Anne M. Ambia 42 Rh and Other Blood Group Alloimmunizations 431 Kenneth J. Moise Jr 43 Preterm Labor 443 Hyagriv N. Simhan 44 Prevention of Preterm Birth 449 Anna King and Sarah J.E. Stock 45 Premature Rupture of the Membranes 461 Brian M. Mercer 46 Indicated Late‐Preterm and Early‐Term Deliveries 475 Catherine Y. Spong 47 Chorioamnionitis 481 Catalin S. Buhimschi and Irina A. Buhimschi 48 Third‐Trimester Bleeding 493 Ilina D. Pluym and Christina S. Han 49 Amniotic Fluid Embolism 507 Irene A. Stafford and Michael A. Belfort 50 Preeclampsia 517 Michal Fishel Bartal and Baha M. Sibai Part 5 Labor and Delivery 51 Elective Induction of Labor 531 Rachel G. Sinkey 52 Electronic Fetal Heart Rate Monitoring 539 David A. Miller 53 Breech Delivery 555 G. Justus Hofmeyr, and Mercy‐Nkuba Nassali 54 Vaginal Birth After Cesarean 563 James R. Scott 55 Placenta Accreta Spectrum 571 Robert M. Silver and Deirdre J. Lyell 56 Shoulder Dystocia 581 George A. Macones and Robert B. Gherman 57 Twins, Triplets, and Beyond 587 Mary E. D’Alton 58 Postpartum Hemorrhage 601 David B. Nelson Appendix A: Evaluation of Fetal Health and Defects 613 Lynn L. Simpson Index 629
About the Editors JOHN T. QUEENAN, MD, Professor and Chairman Emeritus, Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC, USA. CATHERINE Y. SPONG, MD, is a Professor and Vice Chair in the Department of Obstetrics and Gynecology at University of Texas Southwestern Medical Center, Dallas, TX, USA. She also serves as Chief of the Department's Division of Maternal-Fetal Medicine. CHARLES J. LOCKWOOD, MD, MHCM, is Senior Vice President of USF Health, Dean of Morsani College of Medicine and a Professor of Obstetrics and Gynecology, and Public Health at the University of South Florida in Tampa, FL, USA.
