Prostaglandins, Leukotrienes, and the Immune Response

John L. Ninnemann

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English

Cambridge University Press
06 February 1989

Biochemical immunology

This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.

By: John L. Ninnemann
Imprint: Cambridge University Press
Country of Publication: United Kingdom
Dimensions: Height: 228mm, Width: 152mm, Spine: 17mm
Weight: 505g
ISBN: 9780521334839
ISBN 10: 0521334837
Pages: 236
Publication Date: 06 February 1989
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Foreword James S. Goodwin; Preface; 1. A brief history and introduction; 2. Prostaglandin/leukotriene structure and chemistry: a primer; 3. Monocytes and macrophages; 4. Lymphocyte response; 5. Inflammation and the neutrophil; 6. Malignancy and the arachidonic acid cascade; 7. Tissue and organ transplantation; 8. Rheumatoid arthritis and autoimmunity; 9. Traumatic injury and surgery; 10. Allergy; Index.