J.N. Plevris MD, PhD, FRCP(E) Consultant Gastroenterologist & Senior Lecturer, Centre for Liver & Digestive Disorders, The Royal Infirmary of Edinburgh and Hepatology Laboratory, University of Edinburgh Medical School, Edinburgh, UK Subrata Ghosh MD (Edin) FRCP, FRCP (E) Gastrointestinal section, Imperial College School of Medicine, London, UK Colin W. Howden MD, PhD Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, USA