Prions

The New Biology of Proteins

Claudio Soto

$420

Hardback

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English

CRC Press Inc
20 December 2005

Diseases & disorders; Animal pathology & diseases; Biotechnology

Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy --brought prion-related diseases international attention. Exceptionally dramatic, these diseases progressively and inexorably destroy the cognitive, motor, and sensorial skills that are the essence of human beings. Prions: The New Biology of Proteins provides a well-organized overview of what is known about prion-related diseases. This comprehensive work reviews the symptoms, epidemiology, and neuropathology of the disease. It focuses on evidence supporting the idea that TSEs result from a novel disease mechanism: transmission by replication of the misfolding of a single protein in the absence of nucleic acids. Following this hypothesis, the book examines the structure, conversion, and mechanism of prion propagation and details its cellular biology. It explores the transmission, discusses the challenges involved with diagnosis, and considers various therapeutic avenues that are presently being explored. A cohesive volume that integrates the pioneering work of many researchers, this book is authored by Claudio Soto, an internationally renowned researcher whose innovative work has led to an increased understanding of the heretical biology of prions and the development of novel strategies for treating and diagnosing neurodegenerative diseases. As protein misfolding diseases are his specialty, Soto also looks at the phenomenon from a wider perspective. He examines other diseases that display folding aberrations, considers how commonly such aberrations occur in nature, and asks readers to open their minds to consider the impact of prions on broader areas of biology, public health, and biotechnological strategies.

By: Claudio Soto
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions: Height: 234mm, Width: 156mm, Spine: 18mm
Weight: 510g
ISBN: 9780849314421
ISBN 10: 0849314429
Pages: 190
Publication Date: 20 December 2005
Audience: Professional and scholarly , College/higher education , Postgraduate, Research & Scholarly , Undergraduate , A / AS level
Format: Hardback
Publisher's Status: Active

Soto, Claudio

PERHAPS A GIFT VOUCHER FOR MUM?: MOTHER'S DAY

Prions

The New Biology of Proteins

Claudio Soto

$420

Hardback

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