This book provides readers with an anaesthesia-focused alternative to general physiology textbooks. The new edition has been reorganised with the trainee anaesthesist in mind, into shorter bite-sized chapters ideal for exam revision. The content includes the physiology of all major organ systems, with specific emphasis on the nervous, respiratory, and cardiovascular systems as well as special sections on pain, aging, specific environments and obesity. Alongside the learning objectives, reflection points and a handy summary of physiological equations and tables, there is greater emphasis on clinical application in this fourth edition, with applied physiology included in almost every section.
Preface to the first edition Preface to the second edition Preface to the third edition Preface to fourth edition Acknowledgements Authors Contributors Section One: Basic Cell Physiology 1. Cell Components and Function 2. Physiology of Excitable Cells 3. Neurotransmitters and Receptors, Ion Channels, G Proteins and Second Messengers Section Two: Physiology of the Nervous System 4. Neuronal Function 5. Blood-Brain Barrier and Cerebrospinal Fluid (CSF) 6. Cerebral Circulation 7. Spinal Cord: Anatomical and Physiological Features 8. Sensory System 9. Motor Function and Control: Descending Tracts 10. Autonomic Nervous System 11. Consciousness, EEG, Sleep and Emotions Section Three: Muscle Physiology 12. Striated Muscles: Skeletal and Cardiac Muscles 13. Muscle Spindles, Golgi Tendon Organs and Spinal Reflexes 14. Smooth Muscle Section Four: Respiratory Physiology 15. Functions of the Respiratory System 16. Mechanical Properties of the Lungs 17. Gas Exchange in the Lungs 18. Carriage of Oxygen in Blood 19. Carbon Dioxide Carriage in Blood 20. Pulmonary Circulation 21. Control of Ventilation 22. Applied Respiratory Physiology Section Five: Cardiovascular Physiology 23. Functions of the Cardiovascular System 24. Electrical Properties of the Heart 25. Mechanical Events of the Cardiac Cycle 26. Pressure-Volume Loop of the Left Ventricle 27. Physical Factors Governing Blood Flow Through Vessels 28. The Systemic Circulation 29. Microcirculation 30. Venous Return and Vascular Function 31. Regulation of Arterial Blood Pressure 32. Integrated Cardiovascular Responses Section Six: Gastrointestinal Physiology 33. Saliva, Swallowing, and Lower Oesophageal Sphincter 34. Stomach: Gastric Secretions, Motility, Digestion and Vomiting 35. The Small Intestine: Secretions, Digestion and Motility 36. The Large Intestine Section Seven: Liver Physiology 37. Functions of the Liver 38. Liver Blood Flow 39. Liver Function Tests and Physiological Features of Liver Failure Section Eight: Renal Physiology 40. Functions of the Kidneys and Functional Anatomy 41. Renal Blood Flow 42. Glomerular Filtration 43. Tubular Function 44. The Loop of Henle and Production of Concentrated Urine: Counter-Current Mechanisms of the Kidney 45. Overview of Renal Control of Acid-Base Balance 46. Applied Physiology: Renal Failure Section Nine: Acid-Base Physiology 47. Basic Concepts of Acid-Base Physiology 48. Compensatory Mechanisms in Acid-Base Disorders 49. Clinical Aspects of Acid-Base Control 50. Anion Gap and Stewart's Strong Ion Difference Section Ten: Physiology of Blood 51. Cellular Components of Blood 52. Plasma: The Non-Cellular Components of Blood 53. Haemostasis 54. Blood Transfusion Section Eleven: Physiology of the Immune System 55. Immune System and Innate Immunity 56. Acquired Immunity 57. Cytokines 58. Hypersensitivity Section Twelve: Endocrine Physiology 59. General Aspects of Endocrine Physiology 60. Pituitary Gland 61. Hormones of the Pancreas 62. Thyroid Hormones and Calcium Metabolism 63. Hormones of the Adrenal Gland 64. Erythropoietin, Atrial Natriuretic Peptide and Sex Hormones Section Thirteen: Metabolism, Nutrition, Exercise and Temperature Regulation 65. Metabolism 66. Nutrition 67. Exercise Physiology 68. Temperature Regulation Section Fourteen: Physiology of Pain 69. Peripheral Mechanisms of Pain 70. Central Modulation of Pain 71. Pain Sensitization Section Fifteen: Physiology of Pregnancy, Placenta, Neonate, Ageing and Obesity 72. Physiology of Pregnancy 73. Physiology of the Placenta 74. Physiology of the Neonate 75. Physiology of Ageing 76. Physiology of Obesity Section Sixteen: Special Environments 77. Physiology Related to Special Environments Further reading Index
Peter Kam MBBS, MD, FRCA, FANCZA, FFARCSI, FHKCA (Hon) Nuffield Professor of Anaesthetics, Sydney Medical School, University of Sydney Royal Prince Alfred Hospital Camperdown, Australia Ian Power BSc (Hon), MD, FRCA, FFPMANZCA, FANZCA, FRCSEd, FRCP Edin, FFPFRCA Emeritus Professor at the University of Edinburgh, Edinburgh, United Kingdom