Polymyxin Antibiotics

From Laboratory Bench to Bedside

Jian Li, Roger L. Nation, Keith S. Kaye

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English

Springer Nature Switzerland AG
12 August 2019

Pharmacology; Bacteriology (non-medical)

Series: Advances in Experimental Medicine and Biology

Summary
Details

This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field.

It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research.

This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative ‘superbugs’.

Edited by: Jian Li, Roger L. Nation, Keith S. Kaye
Imprint: Springer Nature Switzerland AG
Country of Publication: Switzerland
Edition: 2019 ed.
Volume: 1145
Dimensions: Height: 254mm, Width: 178mm,
Weight: 928g
ISBN: 9783030163716
ISBN 10: 3030163717
Series: Advances in Experimental Medicine and Biology
Pages: 366
Publication Date: 12 August 2019
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active