Phosphoinositides I

Enzymes of Synthesis and Degradation

Tamas Balla, Matthias Wymann, John D. York

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English

Springer
14 March 2012

Cytology; Cellular biology (cytology)

Series: Subcellular Biochemistry

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Edited by: Tamas Balla, Matthias Wymann, John D. York
Imprint: Springer
Edition: 2012 ed.
Volume: 58
Dimensions: Height: 235mm, Width: 155mm, Spine: 25mm
Weight: 724g
ISBN: 9789400730113
ISBN 10: 940073011X
Series: Subcellular Biochemistry
Pages: 356
Publication Date: 14 March 2012
Audience: College/higher education , Further / Higher Education
Format: Hardback
Publisher's Status: Active

1. The Phosphatidylinositol 4-kinases: Don’t Call it a Comeback.- 2. PIP kinases from the cell membrane to the nucleus.- 3. The Phospholipase C Isozymes and Their Regulation.- 4. Phosphoinositide 3-Kinases – A Historical Perspective.- 5. PI 3-kinases – drug targets in inflammation and cancer.- 6. Phosphoinositide 3-kinases in health and disease.- 7. Phosphoinositide phosphatases: just as important as the kinases.- 8. The PTEN and myobubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.