Pharmaceutical Biocatalysis: Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients

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Peter Grunwald

Pharmaceutical Biocatalysis

Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients

Peter Grunwald

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Hardback

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English

Pan Stanford Publishing Pte Ltd
20 December 2019

Medicine: general issues; Pharmacology; Biomedical engineering; Pharmaceutical technology; Environmental science, engineering & technology

This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.

Edited by: Peter Grunwald
Imprint: Pan Stanford Publishing Pte Ltd
Country of Publication: Singapore
Dimensions: Height: 229mm, Width: 152mm,
Weight: 1.750kg
ISBN: 9789814800808
ISBN 10: 9814800805
Pages: 862
Publication Date: 20 December 2019
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Peter Grunwald