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Percutaneous Absorption

Drugs, Cosmetics, Mechanisms, Methods

Nina Dragićević Howard Maibach (University of California San Francisco, USA)

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English
CRC Press
29 January 2024
Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel.

Key Features:

Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption

Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery

Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption

Edited by:   , ,
Imprint:   CRC Press
Country of Publication:   United Kingdom
Edition:   5th edition
Dimensions:   Height: 254mm,  Width: 178mm, 
Weight:   453g
ISBN:   9781032022079
ISBN 10:   1032022078
Series:   Drugs and the Pharmaceutical Sciences
Pages:   990
Publication Date:  
Audience:   Professional and scholarly ,  Undergraduate
Format:   Paperback
Publisher's Status:   Active

"Dr. Nina Dragićević is a professor in Pharmaceutical technology at the Department of Pharmacy at the Singidunum University in Belgrade, Serbia. She earned her master’s degree at the University of Belgrade, Faculty of Pharmacy, in 1999 and subsequently earned a Magister Degree and a PhD (summa cum laude, Dr. rer. nat.) in Pharmaceutical technology from the University of Belgrade and the Friedrich-Schiller University Jena, Germany, respectively. Before her employment at the University Singidunum, Dr. Dragićević worked as an accredited specialist in Pharmaceutical technology in the state pharmaceutical chain Apoteka ""Beograd"" in Belgrade. From 2007 to 2013 she was responsible for the preparation of compounded drugs for different routes of administration in pharmacies of Apoteka ""Beograd"", and in 2013 she was appointed director of the Production Department in the same company. She has published in a variety of international journals and she is editor of six books. Professor Howard I. Maibach, Ph.D. is currently serving as Professor of Dermatology at the University of California, San Francisco. He earned his MD from Tulane University, New Orleans, LA in 1955. Later he served in faculty positions in various levels at the UCSF. Dr. Maibach has over 2,520 published manuscripts. He has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatological Society and the Internal Commission on Occupation Health."

Reviews for Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods

"""Understanding dermal absorption and developing mathematical models for absorption and dermal drug development is a complex process. This book is intended for scientists working in dermal absorption, degradation, and toxicities of drugs, cosmetics, and chemicals, who will find it informative. With a few new chapters, this book could be considered a comprehensive and updated reference. There are several books related to this subject matter in the marketplace, but each focuses on a particular area of the broader topic. Thus, this reference is a must-have in a library. "" - Rahmat M. Talukder, PhD, RPh(The University of Texas at Tyler) Over the last three decades, vesicular phospholipid nanocarriers have been used successfully as tools to improve dermal and transdermal drug delivery as well as in the cosmetic field. The most common nanocarriers used for skin delivery are liposomes. However, since they have failed in efficiently delivering drugs across the intact skin, intensive research has been devoted to the development of new lipid vesicles that are capable of improving this process. Invasomes represent a new class of vesicles, developed by introducing a mixture of terpenes and ethanol to the classic composition of liposomes, which have shown interesting results both in dermal and transdermal drug delivery. The book “Invasomes as Drug Nanocarriers for Innovative Pharmaceutical Dosage Forms “ provides a comprehensive source of information for researchers from both academia and industry. The first chapter deals the skin as a drug delivery route while the next chapter is a comprehensive overview on vesicular phospholipid nanocarriers. Then, the book content deals with preparation, characterization and evaluation of Invasomes, properly designed for delivering drugs and cosmetic active to the skin. Overall, the book provides readers with comprehensive knowledge about these nanocarriers, since the author of the book is one of the main researchers in the field of Invasomes. - Professor Chiara Sinico, University of Cagliari-Italy"


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