Sally C. Pias, PhD, is an Associate Professor in the Department of Chemistry at the New Mexico Institute of Mining and Technology (New Mexico Tech) in Socorro, New Mexico, USA. She specializes in the biophysics of molecular transport processes important in energy metabolism, tumor cell survival, and cell death. Qi Wang, PhD, is an Assistant Professor of Biochemistry in the Department of Chemistry and Biochemistry at Presbyterian College in Clinton, South Carolina, USA. Her research uses molecular dynamics simulations to explore how biomolecular systems interact and change, with focus on membranes and proteins. Joseph C. LaManna, PhD, is Jeannette M. and Joseph S. Silber Professor for the Study of Brain Sciences, affiliated with the Departments of Physiology and Biophysics; Neurology; and Neuroscience at Case Western Reserve University Medical School, Cleveland, Ohio, USA. His research focuses on physiological adaptations to mild hypoxia and on brain metabolism of ketones as an alternate fuel to glucose.