Nuclear Receptors

From Structure to the Clinic

Iain J. McEwan, Raj Kumar

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English

Springer International Publishing AG
29 August 2015

Cellular physiology; Endocrinology; Molecular biology

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.

The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.

Edited by: Iain J. McEwan, Raj Kumar
Imprint: Springer International Publishing AG
Country of Publication: Switzerland
Edition: 1st ed. 2015
Dimensions: Height: 235mm, Width: 155mm, Spine: 16mm
Weight: 633g
ISBN: 9783319187280
ISBN 10: 3319187287
Pages: 236
Publication Date: 29 August 2015
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Reviews for Nuclear Receptors: From Structure to the Clinic

Given the rapid advances in the field of nuclear receptor research, especially their role in cell proliferation, metabolism, and homeostasis, which make them prime targets for a wide range of diseases such as cancer and metabolic diseases, this book does an excellent job of covering their structure and function and translational opportunities for drug discovery. ... The book targets students, scientists, and other clinicians such as oncologists and endocrinologists interested in the field of nuclear receptors. (Omer Iqbal, Doody's Book Reviews, October, 2015)