Non-Invasive Monitoring of Transdermal Drug Delivery

Pasquale Arpaia (Università degli Studi di Napoli Federico II), Umberto Cesaro, Nicola Moccaldi (Università degli Studi di Napoli Federico II) , Isabella Sannino

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English

CRC Press
29 July 2024

Pharmacy & dispensing

The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

By: Pasquale Arpaia (Università degli Studi di Napoli Federico II), Umberto Cesaro, Nicola Moccaldi (Università degli Studi di Napoli Federico II), Isabella Sannino
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 453g
ISBN: 9780367771898
ISBN 10: 0367771896
Pages: 174
Publication Date: 29 July 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Pasquale Arpaia is Team Leader at European Organization for Nuclear Research (CERN). Umberto Cesaro is currently an Adjunct Professor and a Graduate Engineer with the University of Naples Federico II. Nicola Moccaldi is a Research Fellow with CRdC Tecnologie Scarl, Naples, Italy. Isabella Sannino works at Cranfield University (England) in Mechatronic Laboratory of Advanced Vehicle Engineering Centre focusing on driver’s neuromuscular dynamics.

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Non-Invasive Monitoring of Transdermal Drug Delivery

Pasquale Arpaia (Università degli Studi di Napoli Federico II), Umberto Cesaro, Nicola Moccaldi (Università degli Studi di Napoli Federico II) , Isabella Sannino

$103

Paperback

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