Nicotine Safety and Toxicity

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Neal L. Benowitz (Professor of Medicine and Chief of the Division of Clinical Pharmacology, University of California, San Francisco)

Nicotine Safety and Toxicity

Neal L. Benowitz (Professor of Medicine and Chief of the Division of Clinical Pharmacology, University of California, San Francisco)

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English

Oxford University Press Inc
01 August 1998

Medical research; Medical screening; Hygiene; Oncology; Medical toxicology

Nicotine has been developed as a medication to assist smoking cessation, and is being considered as a possible drug for long-term maintenance of non-smoking. It is also undergoing evaluation as a possible treatment for several medical disorders, including ulcerative colitis, Alzheimer's disease, Parkinson's disease, Tourette's syndrome, attention deficit disorder, spasticity, and sleep apnea. Understanding its safety and toxicity is essential for drug developers, drug regulators, and clinicians making risk/benefit decisions about long-term nicotine therapy. Research on nicotine toxicity is also relevant to ongoing research on tobacco and health aimed at understanding the role of nicotine in contributing to tobacco-induced diseases. This book reviews the current scientific understanding of the safety and toxicity of nicotine. The discussion ranges from chemistry, studies in animals and human experimental research to the results of large clinical trials. Among the topics covered are cardiovascular disease, cancer, reproductive toxicity (including fetal toxicity and Sudden Infant Death Syndrome), behavioral toxicity (including abuse liability and addiction to nicotine medication), and gastrointestinal disease. Finally, contributions explore the risks and benefits of nicotine as a medication. The authors are world-renowned experts on their respective topics. No other book addresses nicotine toxicity in the depth or breadth of this volume. A book on the cutting edge of contemporary public health discourse, Nicotine Safety is an up-to-date and lucid overview of current knowledge on the subject. It will be a necessary addition to the bookshelves of clinicians with an interest in tobacco and health, drug developers and researchers, pharmacologists and toxicologists, public health researchers and policy-makers.

Edited by: Neal L. Benowitz (Professor of Medicine and Chief of the Division of Clinical Pharmacology University of California San Francisco)
Imprint: Oxford University Press Inc
Country of Publication: United States
Dimensions: Height: 242mm, Width: 161mm, Spine: 21mm
Weight: 556g
ISBN: 9780195114966
ISBN 10: 0195114965
Pages: 215
Publication Date: 01 August 1998
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Reviews for Nicotine Safety and Toxicity

This book is very useful for scientific/clinicians in the nicotine research field, but will also be informative to scientists in associated fields. --Doody's Journal The chapters in the various sections of the book are by and large scholarly reviews of the information available and are remarkably free of redundancy. Dr. Benowitz himself is the premier authority on the cardiovascular effects of nicotine preparations, and his discussion of the pharmacokinetic and pharmacodynamic aspects reflects his expertise in the area. In addition, there are thoughtful, comprehensive sections on nicotine and cancer and on nicotine and the reproductive system.... Dr. Benowitz's scholarly review not only guides us in the use of nicotine products but also points out potential areas of concern in the use of new nicotine-like drugs. This is a useful and timely book. --The New England Journal of Medicine Benowitz is an internationally recognized expert in the smoking area, with a reputation for excellent research and effective advocacy. Not surprisingly, he has assembled an excellent group of authors to contribute to the book... clearly and consistently written...a succinct starting point for individuals interested in the topics. -- Edward M. Sellers MD, Canadian Journal of Clinical Pharmacology, Vol 7 , No 1, Spring 2000