Neuroepigenomics in Aging and Disease

Raul Delgado-Morales

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Hardback

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English

Springer International Publishing AG
31 May 2017

Medical genetics; Genetics (non-medical); Proteins

Series: Proteomics, Metabolomics, Interactomics and Systems Biology

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease).

The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

Edited by: Raul Delgado-Morales
Imprint: Springer International Publishing AG
Country of Publication: Switzerland
Edition: 1st ed. 2017
Volume: 978
Dimensions: Height: 235mm, Width: 155mm, Spine: 30mm
Weight: 1.212kg
ISBN: 9783319538884
ISBN 10: 3319538888
Series: Proteomics, Metabolomics, Interactomics and Systems Biology
Pages: 525
Publication Date: 31 May 2017
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Raúl Delgado-Morales holds a PhD in Neuroscience. He completed his doctoral studies at the Universitat Autònoma de Barcelona working on the field of epigenetics on depression. He continued his research as a postdoc at the Max Planck Institute of Psychiatry in Munich. Dr. Delgado-Morales currently works as a postdoctoral researcher at the Bellvitge Biomedical Research Institute (IDIBELL), in Barcelona, Spain in the field of neuroepigenomics.