Over the past decade, developmental neurobiology has made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. In this volume, the editors bring together some of the most active investigators in this field. Each contributor provides a state-of-the-art overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models and sets the scene for future efforts at early detection and prevention of schizophrenia. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.
1. Genes and brain development Timothy A. Klempan, Pierandrea Muglia and James L. Kennedy; 2. Brain development in healthy children and adolescents: magnetic resonance imaging studies Jay N. Giedd, Michael A. Rosenthal, A. Blythe Rose, Jonathan D. Blumenthal, Elizabeth Molloy, Richard R. Dopp, Liv S. Clasen, Daniel J. Fridberg and Nitin Gogtay; 3. Cognitive development: fMRI studies Beatriz Luna and John Sweeney; 4. Cognitive development in adolescence: cerebral underpinnings, neural trajectories and the impact of aberrations Stephen J. Wood, Cinzia R. DeLuca, Vicki Anderson and Christos Pantelis; 5. Brain plasticity and long-term function after early cerebral insult: the example of very preterm birth Matthew Allin, Chiara Nosarti, Larry Rifkin and Robin M. Murray; 6. Do degenerative changes operate across diagnostic boundaries? The case for glucocorticoids involvement in major psychiatric disorders Carmine M. Pariante and David Cotter; 7. Velo-cardio-facial syndrome (deletion 22q11.2): a homogeneous neurodevelopmental model for schizophrenia Stephan Eliez and Carl Feinstein; 8. Can structural MRI provide an alternative phenotype for genetic studies of schizophrenia? Colm McDonald and Robin M. Murray; 9. Nutritional factors and schizophrenia Sahebarao P. Mahadik; 10. Schizophrenia, neurodevelopment, and epigenetics Arturas Petronis; 11. Early environmental risk factors for schizophrenia Mary Cannon, Kimberlie Dean and Peter B. Jones; 12. Transcriptomes in schizophrenia: assessing altered gene expression with microarrays David A. Lewis, Karoly Mirnics and Pat Levitt; 13. Is there a role for social factors in a comprehensive development model for schizophrenia? Jane Boydell, Jim Van Os and Robin M. Murray; 14. How does drug abuse interact with familial and developmental factors in the aetiology of schizophrenia? Chih-Ken Chen and Robin M. Murray; 15. Developmental dysregulation of the dopamine system and the pathophysiology of schizophrenia Anthony A. Grace; 16. The development of 'mis-wired' limbic lobe circuitry in schizophrenia and bipolar disorder Francine M. Benes; 17. Development of thalamocortical circuitry and the pathophysiology of schizophrenia Darlene S. Melchitzky and David A. Lewis; 18. X chromosome, estrogen, and brain development, implications for schizophrenia Michael Craig, William Cutter, Ray Norbury and Declan Murphy; 19. Premorbid structural abnormalities in schizophrenia Stephen M. Lawrie; 20. Neurodegenerative models of schizophrenia L. Fredrik Jarskog, John H. Gilmore and Jeffrey A. Lieberman; 21. Does disordered brain development cut across diagnostic boundaries? Christian W. Kreipke, David R. Rosenberg and Matcheri S. Keshavan; 22. Can one identify preschizophrenic children? Eugenia Kravariti, Paola Dazzan, Paul Fearon and Robin M. Murray; 23. High risk studies, brain development and schizophrenia Matcheri S. Keshavan; 24. Developmental models and hypotheses-driven early interventions in schizophrenia Matcheri S. Keshavan and Barbara A. Cornblatt.
Matcheri S. Keshavan, M.D., FRCPC MRCPsych is Professor of Psychiatry at the University of Pittsburgh School of Medicine and Director of the Clinical Core, Center for the Neuroscience of Mental Disorders, and Director of the STEP Clinic at the University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic. James L. Kennedy, M.D., FRCPC, is Director of the Neuroscience Research Department, and Head, Section of Neurogenetics, at the Centre for Addiction and Mental Health, and also Professor of Psychiatry and Medical Sciences at the University of Toronto. Robin M. Murray, DSc, FRCPsych is Professor of Psychiatry and Head of the Department of Psychological Medicine at the Institute of Psychiatry, King's College, University of London, as well as Consultant Psychiatrist at the Maudsley Hospital, London.
Reviews for Neurodevelopment and Schizophrenia
Review of the hardback: '... an excellent book that delivers a scientific map of recent neurodevelopmental concepts.' British Journal of Neuroscience Nursing Review of the hardback: '... a well-balanced and comprehensive overview that merits to be read by all students of this fascinating and devastating disorder.' Genes, Brain and Behaviour
