Neurobiology of Aging: Exploring Cognitive Decline and Neurodegeneration

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Sachchida Nand Rai, PhD (Research Associate, Banaras Hindu University, Varanasi, India)

Neurobiology of Aging

Exploring Cognitive Decline and Neurodegeneration

Sachchida Nand Rai, PhD (Research Associate, Banaras Hindu University, Varanasi, India)

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English

Academic Press Inc
01 December 2025

Maturation & ageing; Neurology & clinical neurophysiology; Neurosciences

Neurobiology of Aging: Exploring Cognitive Decline and Neurodegeneration is a comprehensive reference exploring the complexities of the aging brain. This book examines the intricate processes driving cognitive decline and neurodegeneration. From the gradual loss of neurons and synapses to the formation of protein aggregates characteristic of Alzheimer's disease, each chapter reviews key aspects of brain aging. Chapters dissect the mechanisms driving neuronal loss, synaptic dysfunction, and protein misfolding, shedding light on the intricate interplay of oxidative stress, inflammation, and mitochondrial dysfunction. This book also navigates through strategies for healthy brain aging, from the impact of diet and exercise to the role of cognitive stimulation.

Edited by: Sachchida Nand Rai PhD (Research Associate Banaras Hindu University Varanasi India)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 276mm, Width: 216mm,
Weight: 450g
ISBN: 9780443362958
ISBN 10: 0443362955
Pages: 342
Publication Date: 01 December 2025
Audience: Professional and scholarly , College/higher education , Undergraduate , Further / Higher Education
Format: Paperback
Publisher's Status: Active

Part 1: Mechanisms of Brain Aging 1. Introduction to the Neurobiology of Aging 2. Neuronal Loss and Synaptic Dysfunction 3. Protein Misfolding and Aggregation and its role in dementia with Lewy bodies 4. Oxidative Stress and Aging 5. Inflammation: Chronic Inflammation in Aging Part 2: Factors Influencing Brain Aging 6. Mitochondrial Dysfunction and Aging 7. Neurotransmitter Systems in Aging 8. Genetic Influences on Aging and Neurodegenerative Diseases 9. Environmental and Lifestyle Factors in Brain Aging 10. The Role of Diet in Brain Health Part 3: Interventions and Strategies for Healthy Brain Aging 11. Exercise and Cognitive Function in Aging 12. Unlocking Cognitive Vitality: The Interplay of Stimulation, Sleep, and Brain Aging 13. Exploring the Multifaceted Links Between Comorbidities and Cognitive Aging 14. Therapeutic Approaches to Age-Related Cognitive Decline and Neurodegenerative Diseases 15. Exploring Promising Pharmaceutical Candidates for Anti-Aging

Dr. Sachchida Nand Rai is a Biochemistry Research Associate at Banaras Hindu University’s Institute of Science. He obtained his MSc in Biochemistry from Purvanchal University, India, and his PhD in Biochemistry from Banaras Hindu University, India. Dr. Rai researches the anti-oxidative and anti-neuroinflammatory properties of phytochemicals for the treatment of neurodegenerative diseases. He is a lifetime member of the Indian Academy of Neuroscience.