Neuro-Urology Research: A Comprehensive Overview

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Anne M.J. Verstegen (Medicine Department, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts)

Neuro-Urology Research

A Comprehensive Overview

Anne M.J. Verstegen (Medicine Department, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts)

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English

Academic Press Inc
12 May 2023

Urology & urogenital medicine; Neurosciences

"Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field including the latest discoveries, explains in detail some of the neuroscience tools that can be used when studying the neural control of the lower urinary tract, and discusses potential future directions for research. The first section, Neuroscience in Urology Research, reviews neuro-regulators and the important anatomical brain sites. It also provides an overview of voluntary versus reflex micturition control and describes how bladder physiology readout is a useful tool in research. The second section, Fundamental and Translational Neuro-Urology Research, discusses the translational potential of basic research for patients and the impact of neuro-urology research on clinical practice. Chapters in this section provide more insight into pathologies endemic to specific patient populations and areas for treatment development opportunities. The third section, Neurobiological Tools Applied to Neuro-Urology Research, supplements the ‘A Quick Guide to the ""Neuroscience Toolbox""’ and introduces research techniques such as RNA sequencing and calcium imaging of neural activity. The fourth and final section, aptly titled Research Directions and Research Opportunities, covers research directions that remain underexplored or have high therapeutic potential. Research in neuro-urology presents a route to understanding how bladder function is controlled and how urinary continence is maintained. This book provides a platform for researchers to initiate collaborations on the many underexplored research topics and to consolidate knowledge, ultimately lending itself to a coordinated and multi-center research approach that will benefit the field."

Edited by: Anne M.J. Verstegen (Medicine Department Beth Israel Deaconess Medical Center Boston Massachusetts; Harvard Medical School Boston Massachusetts)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 235mm, Width: 191mm,
Weight: 730g
ISBN: 9780128224557
ISBN 10: 012822455X
Pages: 258
Publication Date: 12 May 2023
Audience: Professional and scholarly , College/higher education , Undergraduate , Further / Higher Education
Format: Paperback
Publisher's Status: Active

1. Neuro-Urology Research: A Comprehensive Overview Section I - Neuroscience in Urology Research 2. Barrington’s Nucleus: A Century of Progress Identifying the Neurons that Control Micturition 3. Voluntary versus Reflex Micturition Control 4. The Bladder as a Readout in Neuroscience Research Section II - Fundamental and Translational Neuro-Urology Research 5. How Treatment of LUTS can Benefit from Basic Research 6. Lower Urinary Tract Symptoms in Patients with Neurological Disorders 7. Effect of Androgens and Estrogens on Bladder and Lower Urinary Tract Function Section III - Neurobiological Tools Applied to Neuro-Urology Research 8. Transcriptomic Identification of Cell Types in the Lower Urinary Tract 9. Exploring Urinary Bladder Neural Circuitry through Calcium Imaging Section IV - Research Directions and Research Opportunities 10. The Periaqueductal Gray and Control of Bladder Function 11. Impact of Spinal Neuromodulation on Spinal Neural Networks Controlling Lower Urinary Tract Function 12. Neural Control of Continence

Dr. Verstegen has a broad background in research and with specific training in key areas of molecular and cellular biology, behavioral and systems neuroscience, and with expertise in stereotaxic surgery techniques, design and execution of experimental paradigms coupled with optogenetics, and mouse genetics. She graduated in Experimental and Clinical Neuroscience at Utrecht University (NL) and obtained a Ph.D. degree at the Italian Institute of Technology (IIT). Her current research projects aim to identify the neural networks that control urine storage and voiding. Because disturbances in the brain control of the bladder and sphincter can cause or contribute to LUTS, understanding these control circuits may lead to potential therapies. Besides unraveling and mapping the neural circuitry, she is interested in understanding which neuro-regulators are involved and in associating function with distinct neuron subpopulations in aspects of bladder control.