This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. The book intends to elaborate functional outcomes of component-to-component relationships using rodent and nonhuman primate in vitro and in vivo models that allow for the directional and quantitative description of the complete organism in response to environmental perturbations. In addition, attention has also been directed to some of the more recent methodologies, including genomics, proteomics and metabolomics, applied in the evolutionary neurobiological field.
, William Slikker
Country of Publication:
13 February 2017
Professional and scholarly
Neurons -- Nerve Cells Fang Liu, Tucker A. Patterson, Jingshu Zhang, Merle G. Paule, William Slikker, Jr. and Cheng Wang Astrocytes Cheng Wang, Qi Yin, Shuliang Liu, Xuan Zhang, Fang Liu, Jingshu Zhang, Tucker A. Patterson, Merle G. Paule and William Slikker, Jr. Oligodendrocytes [myelin-related glial cell in the central nervous system (CNS)] Shuliang Liu, Merle G. Paule, Fang Liu, Qi Yin, Tucker A. Patterson, William Slikker, Jr. and Cheng Wang Schwann Cells Xuan Zhang, Tucker A. Patterson, Merle G. Paule, Cheng Wang and William Slikker, Jr. Neuroendocrine Cells Zhen He, Sherry A. Ferguson, Tucker A. Patterson and Merle G. Paule Neural Stem Cells in the Adult Brain: Altered Activity in Aging, Alzheimer's Disease, Mood Disorders and Epilepsy Ashok K. Shetty and Bharathi Hattiangady Neural Stem Cells and Transplantation Malathi Srivatsan 3D in vitro Models for Developmental Neurotoxicity (DNT) Luc Stoppini, Jenny Sandstroem von Tobel, Igor Charvet, Marie-Gabrielle Zurich, Lars Sundstrom and Florianne Monnet-Tschudi Neural Cell Lines (Lineage) Qiang Gu Advanced Cell Techniques to Study Developmental Neurobiology and Toxicology Thomas Hartung, Helena T. Hogberg, Marcel Leist, David Pamies and Lena Smirnova Anesthesia and Neural Plasticity Laszlo Vutskits Blood-Brain Barrier (BBB) Balabhaskar Prabhakarpandian, Syed Ali and Kapil Pant Neurotrophins and Alzheimer's Disease Jyotshna Kanungo Neurotransmitters and Receptors Vesna Jevtovic-Todorovic 15. Neuronal Ion Channels Slobodan M. Todorovic 16. Brain Injury - Neuroprotection Koichi Yuki, Mary Ellen McCann and Sulpicio G. Soriano
Cheng Wang, Ph.D, is a senior scientist at the National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. He also is an adjunct faculty member of the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences (UAMS), Little Rock, USA. Dr. William Slikker is a recognized expert in neurotoxicology and the director of the National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas.