Nanotechnology for Oral Drug Delivery: From Concept to Applications

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João Pedro Martins, MSc Biom. Eng. (Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland) Hélder A. Santos, PhD

Nanotechnology for Oral Drug Delivery

From Concept to Applications

João Pedro Martins, MSc Biom. Eng. (Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland), Hélder A. Santos, PhD

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English

Academic Press Inc
27 July 2020

Pharmaceutical industries; Medical equipment & techniques; Pharmacology; Biomedical engineering; Biotechnology

Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies.

Edited by: João Pedro Martins MSc Biom. Eng. (Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Finland), Hélder A. Santos, PhD
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 234mm, Width: 191mm,
Weight: 1.060kg
ISBN: 9780128180389
ISBN 10: 0128180382
Pages: 534
Publication Date: 27 July 2020
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

"João Pedro Martins graduated in Biomedical Engineering at the Faculty of Engineering of the University of Porto (FEUP) in collaboration with the Institute of Biomedical Engineering (INEB), Porto, Portugal. Currently, he is a fourth-year PhD student at the Faculty of Pharmacy of the University of Helsinki, Finland. In the framework of his PhD, J.P. Martins is developing advanced drug delivery systems with the aim of making oral administration of nanomedicines carrying anti-diabetic drugs a reality. So far, he has authored/co-authored 12 scientific publications (original and review articles), 2 book chapters, and 1 conference proceedings, and has given 8 oral communications and 13 poster presentations in scientific meetings. J.P. Martins has more than 150 citations (Google Scholar 190; h-index = 8), and has also served as a reviewer for 7 international peer-reviewed scientific journals. Prof. Santos (D.Sc. Tech., Chem. Eng.) is a Full Professor in Department of Biomedical Engineering at the University of Groningen. He is also Research Director at the University of Helsinki, Faculty of Pharmacy. Prof. Santos is also the co-founder of the startups Capsamedix Oy and Medixmicro Oy, and Coordinator of MSCA-ITN P4 FIT network in tendon repair (~4.1 m€). He holds Visiting Professorships at the Shanghai Jiao Tong University School of Medicine and University of Tartu. Prof. Santos research interests include the development of nanoparticles/nanomedicines and biomaterials for biomedical applications, particularly cancer and heart diseases. His lab makes the unique bridge between medical engineering, pharmaceutical nanotechnology and tissue engineering by combining unique techniques to develop novel therapeutic formulations for translation into the clinic. He is also in Editorial board member of several international journals, and Associate Editor of Nano Select, Smart Materials in Medicine, and Drug Delivery and Translational Research, among others. Prof. Santos has received prestigious awards/grants, for example, the ""Talent Prize in Science"" in 2010 attributed by the Portuguese Government, ERC Starting Grant in 2013 and ERC Proof-of-Concept Grant in 2018, Young Researcher Award in 2013 attributed by Faculty of Pharmacy, the Academy of Finland Award for Social Impact in 2016, and the CRS Young Investigator Award 2021."