Anatoly B. Kolomeisky
As a chemical physicist dabbling in molecular biophysics, I am particularly intimidated by the subject of molecular machines. Reading much of what is written on this subject is like trying to understand how the internal combustion engine works by looking at the blueprints of a modern car engine, with the added difficulty of the blueprints often being inaccurate or incomplete. In contrast, Kolomeisky goes straight into the heart of the matter and explains why and how fundamental principles of physics and chemistry allow those marvelous molecular assemblies to generate directional motion and to perform every mechanical task in the living organism or cell. The author further describes how this molecular motion is studied experimentally, develops quantitative models that explain experimental observations, and provides a succinct, self-contained, and lucid introduction to the fundamentals of thermodynamics, statistical mechanics, and chemical kinetics relevant to molecular motors as well as to many other biochemical processes. The historical bits dispersed throughout the text make it especially refreshing to read and would be appreciated by any reader who, like myself, is amazed by the progress science has made in understanding the complexity of life. -Dmitrii Makarov, Department of Chemistry, The University of Texas at Austin