Mood Disorders

Table of Contents Chapter 1: Major Depressive Disorder and Bipolar Disorder Introduction Signs and Symptoms Diagnosis of Mood Disorders Major Depressive Disorder Bipolar Disorder Seasonal Affective Disorder (SAD) Conclusion Chapter 2: Major Mood Disorders: Differentiating Features Introduction Allostatic Load Model of Mood Disorders Mood Disorders as Systemic Ailments Differentiating Features of Unipolar and Bipolar Depression Affective Ailments as Spectrum Disorders Psychometric Scales How to Differentiate Between Unipolar and Bipolar Depression? Catatonic Symptoms of Mood Disorders Conclusion Chapter 3: Cormorbidity in Mood Disorders Introduction The Relation Between Mood Disorders and Inflammatory Comorbidity Mechanisms Linking Immune-Inflammatory Imbalance to GMC in Mood Disorders Therapeutic Considerations Conclusion Chapter 4: Etiology- The Role of Epigenetics Introduction The Relationship Between Mood Disorders and Inflammation The Biological Mechanisms Linking Mood Disorders and Inflammation Neuronal Plasticity Childhood Abuse and Mood Disorders The Link Between Childhood Trauma and Inflammation Childhood Trauma and Neuronal Plasticity The Epigenetic Link Future Directions Conclusion Chapter 5: Neurobiology of Mood Disorders- The Circadian Connection Introduction Mood Disorders and the Circadian System The Neurobiology of the Circadian System Conclusion Chapter 6: Pathogenesis of Mood Disorders- The Neuroinflammatory Hypothesis Introduction Neuroinflammation- The Role of Cytokines Inflammation, Kynurenines and Mood Disorders Purported Model of Depression Oxidative Stress Conclusion Chapter 7: Mood Disorders- Staging and Neuroprogression Introduction Developmental Trajectory and Clinical Heterogeneity of Mood Disorders Neuroprogression as the Basis for Staging Mood Disorders Allostatic Load and Neuroprogression Biomarkers of Mood Disorders Staging Models of BD Staging Model for MDD Therapeutic Implications of Staging Limitations of the Staging Models Conclusion Chapter 8: The Management of Treatment Resistant Depression- Monoamines and Beyond Introduction Switching or Combining 1st Line Antidepressants for TRD Combining Atypical Antipsychotics with Standard Antidepressants Voritoxetine in TRD Targeting Other Pathways in TRD Conclusion Chapter 9: Treatment of Bipolar Depression- The Current Perspective Introduction Lithium and Anticonvulsants Atypical Antipsychotics Conclusion Chapter 10: Manic Phase of Bipolar Disorder- Treatment Recommendations Introduction Diagnosis of Mania Treatment of Mania Maintenance Treatment Conclusion Chapter 11: Mood Disorders- Non-Pharmacological Treatments Introduction Psychoeducation Cognitive Behavioral Therapy Interpersonal and Social Rhythm Therapy Dialectical Behavior Therapy Mindfulness-Based Cognitive Therapy Family Therapies Future Directions in Research on Psychological Treatments Conclusion