Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction.
Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food.
Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction.
SECTION I 1. Nutritional Support in Mitochondrial Diseases: The State of the Art 2. Targeting Mitochondrial Dysfunction: Challenges and Opportunities 3. Impact of Mitointeractions On Health-Disease Responses to Diet 4. Mitochondrion at the Crossroads Between Nutrients and Epigenome 5. Inadequate Nutritional Intake in Mitochondrial Diseases 6. Nutritional Deficits Involved in Mitocondrial Damage in Critical Illness SECTION II 7. Mitochondrial Response to Controlled Nutrition in Health and Disease 8. Diet Restriction-Induced Mitochondrial Signalling and Healthy Aging 9. Ketogenic Diets, Mitochondria, and Neurological diseases 10. Ferility Diet and Mitochondrial Function 11. Maternal Nutrient Modulation and Fetal Mitochondrial Gene Expression 12. Dietary Modulation and Mitochondrial DNA Damage SECTION III 13. Vitamin E, Mitochondrial Dysfunction and Aging 14. The Role of B Vitamins in Protecting Mitochondrial Function 15. Triggering Mitochondrion-Dependent Necrosis by Fatty Acids 16. Dietary Lipids and Mitochondrial Gene Expression 17. Dietary EPA and DHA for Mitochondrial Biosynthesis and Dynamics 18. Supplemental Vitamin C for Mitochondrial Biogenesis in Health and Exercise SECTION IV 19. Mitochondria-Targeted Antioxidants: Coezyme Q10, MitoQ and beyond 20. Flavonoids, Mitochondrial Enzymes and Heart Protection 21. Tea Polyphenols Stimulate Mt Bioenergetics in Cardiometabolic Diseases 22. Quercetin and Mitochondria: from Nutrition to Nanomedicine 23. N-acetylcysteine and Up-Regulation of Mitochondrial Biogenesis 24. Dietary Carnitine, Mitochondrial Function and Therapy 25. Creatine Monohydrate for Mitochondrial Nutrition 26. Benefits of Supplemental Arginine and Citrullne in MELAS syndrome 27. Nutraceuticals for Targeting NAD+ to Restore Mitochondrial Function 28. Curcumin for Protecting Mitochondria and Down Regulating Inflammation 29. Dietary Molecular Hydrogen for Mitochondrial Viability 30. Fucoxantin and Mitochondrial Uncoupling Protein-1 in Obesity 31. Rice Bran Extract for the Prevention of Mitochondrial Dysfunction 32. Dietary Modulators of Nuclear Factor Erythroid-2-Related Factor 2 33. Plant Silymarin Affects Mitochondrial Integrity in Stress Conditions 34. Alternative Respiratory Chain Enzymes: Therapeutic Potential and Possible Pitfalls 35. New Mitochondria Permeability Transition Pore Inhibitor Based on Dietary Gallic Acid 36. Plant-Derived Compounds, Vitagens, and Mitochondrial Function 37. Buckwheat Trypsin Inhibitor (rBTI): A Novel Nutrceutical for Mitochondrial Homeostasis in Age-Related Conditions 38. Nutraceutical Effects of Indian Gooseberry on Mitochondria-Mediated Cellular Damage 39. 5-Heptadecylresorcinol from Whol Grain Rye for Mitochondrial Bioactivities 40. Combined Nutraceutical Therapy for Mitochondrial Cytopathies
Dr. Sergej M. Ostojic is a full professor of nutrition at the University of Agder and the University of Novi Sad. His current research follows two main themes: studying mitochondrial viability and targeted nutritional interventions to tackle impaired bioenergetics in health and disease, and analyzing population health metrics in chronic cardiometabolic diseases. To date, he has authored and coauthored over 280 peer-reviewed research and review articles in high-impact journals, such as The Lancet, Nature, The BMJ, Trends in Food Science and Technology, Trends in Endocrinology and Metabolism, Advances in Nutrition, Mayo Clinic Proceedings, Clinical Nutrition, Pharmacological Research, Nutrients, European Journal of Nutrition, and Nutritional Neuroscience. He is a member of the American College of Physicians, the American Society for Nutrition, the American Physiological Society, the International Society for Cerebral Blood Flow and Metabolism, and the Nutrition Society, and has been the recipient of internationally competitive research grants including the WADA Scientific Research Grant, NSCA International Award, and the European Commission, and many industrial endowments. Dr. Ostojic holds eight patents and patent applications in the United States, United Kingdom, European Union, and Japan.
