Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated
Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more.
Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout.
Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies Illustrates the impact of molecular research on hematologic investigations and therapeutics Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools
Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.
List of contributors ix Foreword xiii Preface xv 1 Beginnings: the molecular pathology of hemoglobin 1 Douglas Higgs and Mohsin Badat 2 Stem cells 17 David T. Scadden 3 The genetics of acute myeloid leukemia 33 Amye M. Harrigan and Amy M. Trottier 4 Molecular diagnostics and risk assessment in myeloid malignancies 51 Christian Scharenberg and Torsten Haferlach 5 Molecular basis of acute lymphoblastic leukemia 67 Shunsuke Kimura and Charles G. Mullighan 6 Chronic myelogenous leukemia 83 Hagop Kantarjian, Elias Jabbour and Susan O’Brien 7 Myeloproliferative neoplasms 99 Jessica Spiers, Dina Mahdi, Christopher Saunders and Donal P. McLornan 8 Lymphoma genetics 113 Giovanni Insuasti- Beltran, Chad M. McCall and Eric D. Hsi 9 Molecular basis of chronic lymphocytic leukemia 127 Bita Fakhri and Alexey Danilov 10 The molecular biology of multiple myeloma 137 Udit Yadav and Wilson I. Gonsalves 11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 145 Deena Iskander, Lucio Luzzatto and Anastasios Karadimitris 12 Anemia of chronic disease 169 Tomas Ganz and Elizabeta Nemeth 13 Molecular basis of iron metabolism 175 Jodie L. Babitt and Tomas Ganz 14 Perspectives in genomics and sickle cell disease therapeutics 187 Ambroise Wonkam 15 Molecular coagulation and thrombophilia 201 Björn Dahlbäck and Andreas Hillarp 16 The molecular basis of hemophilia 217 Keith Gomez 17 The molecular basis of von Willebrand disease 231 Omid Seidizadeh and Luciano Baronciani 18 Platelet disorders 251 Kenneth J. Clemetson 19 The molecular basis of blood cell alloantigens 267 Winnie Chong, Louise Tilley and Colin Brown 20 Functions of blood group antigens 285 Jonathan S. Stamler, Marilyn J. Telen and Carla Dinardo 21 Autoimmune hematological disorders 299 Drew Provan and John W. Semple 22 Molecular therapeutics in hematology: gene therapy 321 William M. McKillop and Jeffrey A. Medin 23 Pharmacogenomics 343 Leo Kager and William E. Evans 24 Cancer stem cells 359 Sara Ali and Dominique Bonnet 25 CAR- T cell therapy 369 Jude Franklin, Prateek Pophali, Zachary Jackson, David Wald and David Avigan 26 Molecular basis of transplantation 397 Pramila Krishnamurthy, Victoria Potter and Francesco Dazzi Index 413
DREW PROVAN MD, FRCP, FRCPATH, Emeritus Reader in Autoimmune Hematology, Centre for Immunology, Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK. HILLARD M. LAZARUS, MD, FACP, Professor of Hematology-Oncology, Full Professor of Medicine, The Department of Medicine, Division of Hematology-Oncology, Case Western Reserve University, Cleveland, Ohio 44106.
