Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells. In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes. Since mitochondria are present in every cell, every tissue, mitochondrial disorder usually affects multiple organs.
Edited by:
Lee-Jun C. Wong Imprint: Springer-Verlag New York Inc. Country of Publication: United States Edition: 2013 ed. Dimensions:
Height: 235mm,
Width: 155mm,
Spine: 25mm
Weight: 6.978kg ISBN:9781461437215 ISBN 10: 1461437210 Pages: 372 Publication Date:18 September 2012 Audience:
Professional and scholarly
,
Undergraduate
Format:Hardback Publisher's Status: Active