Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer’s disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold’s reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book.
By:
Elena L. Paley PhD (Adjunct Professor at Nova Southeastern University FL USA)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions:
Height: 235mm,
Width: 191mm,
Weight: 1.060kg
ISBN: 9780443191220
ISBN 10: 0443191220
Pages: 534
Publication Date: 26 January 2023
Audience:
Professional and scholarly
,
Undergraduate
Format: Paperback
Publisher's Status: Active
1. Introduction: Microbial metabolite interference of protein biosynthesis in neurodegenerative, neurodevelopmental, and other disorders; microbial metabolites hijacking vagus nerve 2. COVID-19: Scientific progress 3. Viral-bacterial interactions in diseases 4. Vagus nerve: Acid reflux, parietal cells, carpal tunnel syndrome, Alzheimer’s disease, COVID-19, stroke, cancer, and other diseases 5. Vagus nerve circuit: Microbiome—tryptophan metabolites—receptors and synapses 6. Glutamate and glutamate receptors in vagus nerve pathways and in Alzheimer’s disease 7. Aminoacyl tRNA synthetase multiple forms in autoimmune and infectious diseases 8. Crystalized aromatic l-amino acid decarboxylase from bacteria Micrococcus percitreus catalyzing decarboxylation of tryptophan and l-DOPA (Levodopa or 3,4-dihydroxy-l-phenylalanine) 9. Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water 10. Microbial antigens, allergies, and antibodies to microbial allergens: Significance of preexisting antibodies and stress for vaccination 11. Smell and taste identification deficits in disease 12. Microorganisms producing biogenic amines: From food to human body 13. Human genome or human microbiome genes: Which one is more important for human health and intellectual abilities? 14. Microorganisms used in agriculture, consumed from environment and associated with the edible raw fruits, vegetables, herbs, sprouts, and mushrooms 15. Molecular and cell aggregation: Biogenic amines, proteins, platelets, and microbial pathogens 16. Colonic diverticular disease as a risk factor for neurodegenerative and associated diseases 17. Alzheimer’s disease, dementia, aging, and COVID-19 18. Existing vaccines and new and old tools 19. Serotonin syndrome in neurodegenerative diseases and COVID-19: Mechanisms and consequences of intestinal infection 20. Circulating cell-free mitochondria and membrane vesicles 21. Protein synthesis inhibition in neuronal activities 22. Rosacea and associated medical disorders 23. Bacterial internalization in cancer and other medical conditions: Intracellular pathogens 24. Ocular changes resulting from reading and writing on smartphone and computer: Computer vision syndrome, dry eye disease, meibomian gland dysfunction, chalazion, occupational overuse syndrome 25. Viral infections in vagus nerve 26. Microbial tryptamine in Type 1, Type 2, and Type 3 diabetes
Dr. Paley is Cofounder of the nonprofit Stop Alzheimers Corp and Founder of Expert Biomed, Inc. She holds a PhD degree in biology with specialization in molecular biology from the Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences in the Laboratory of Lev L. Kisselev. Dr. Paley’s research focuses mainly on protein biosynthesis in biology and diseases and is conducted in collaboration with Harvard University, Brandeis University, the University of Miami, Tel Aviv University, the Institut des Vaisseaux et du Sang (Paris, France), and the University of Texas at San Antonio. She is Adjunct Professor at Nova Southeastern University, FL, United States, and is inventor in patents issued and pending.
