Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins
Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved.
An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research.
Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.
Edited by:
Michael K. Johnson,
Robert A. Scott (Department of Chemistry)
Imprint: John Wiley & Sons Inc
Country of Publication: United States
Dimensions:
Height: 280mm,
Width: 222mm,
Spine: 24mm
Weight: 1.361kg
ISBN: 9781119159834
ISBN 10: 1119159830
Series: EIC Books
Pages: 424
Publication Date: 06 October 2017
Audience:
Professional and scholarly
,
Undergraduate
Format: Hardback
Publisher's Status: Active
Contributors ix Series Preface xiii Volume Preface xv Part 1: Assembly and Trafficking of Simple Fe-S Clusters 1 Nif System for Simple [Fe–S] Cluster Assembly in Nitrogen-Fixing Bacteria 3 Patricia C. Dos Santos and Dennis R. Dean Iron–Sulfur Cluster Assembly in Bacteria and Eukarya using the ISC Biosynthesis Machinery 17 Sandrine Ollagnier de Choudens and Hélène Puccio The Suf System in Archaea, Bacteria, and Eukaryotic Organelles 37 Guangchao Dong, Savannah Witcher, F. Wayne Outten and Marinus Pilon Roles of Class II Glutaredoxins in the Maturation of Fe–S Proteins 53 Jonathan Przybyla-Toscano, Thomas Roret, Jérémy Couturier and Nicolas Rouhier Part 2: Assembly of Complex and Heterometallic Fe-S Cluster Active Sites 73 Nitrogenase Metallocluster Assembly 75 Nathaniel S. Sickerman, Lee A. Rettberg, Yilin Hu and Markus W. Ribbe Metallocluster Assembly: Maturation of [FeFe]-Hydrogenases 93 Giorgio Caserta, Ludovic Pecqueur, Cecilia Papini and Marc Fontecave CO Dehydrogenase and Acetyl-CoA Synthase 111 Holger Dobbek Part 3: Assembly of Homometallic and Heterometalic Cu Cluster Active Sites 123 Assembly of Dinuclear Copper Center in Tyrosinases and Hemocyanins 125 Nobutaka Fujieda and Shinobu Itoh Multicopper Oxidases 139 Daniel J. Kosman Assembly of the Redox-Active Metal Centers of Cytochrome c Oxidase 157 Eva Nyvltova, Antoni Barrientos and Jonathan Hosler CuA and CuZ Center Assembly in Nitrous Oxide Reductase 185 Sofia R. Pauleta and Isabel Moura MoCu CO Dehydrogenase and its Active-Site Assembly 197 Frank Mickoleit Part 4: Assembly of Homometallic and Heterometallic Mn Clusters 213 Homo- and Heterometallic Dinuclear Manganese Proteins: Active Site Assembly 215 Gustav Berggren, Daniel Lundin and Britt-Marie Sjöberg Biogenesis and Assembly of the CaMn4O5 Core of Photosynthetic Water Oxidases and Inorganic Mutants 233 Colin Gates, Gennady Ananyev and G. Charles Dismukes Part 5: Assembly of Homometallic and Heterometallic Ni Clusters 249 Urease Activation 251 Robert P. Hausinger Insights into [NiFe]-Hydrogenase Active Site Metallocluster Assembly 261 Robert Gary Sawers and Constanze Pinske Part 6: Assembly of Cofactors for Binding Active-Site Metal Centers 273 Moco in Mo/W Enzymes 275 Silke Leimkühler Heme Biosynthesis 299 Amy E. Medlock and Harry A. Dailey Siroheme Assembly and Insertion to Nitrite and Sulfite Reductase 315 M. Elizabeth Stroupe and Martin J. Warren Biosynthesis of Coenzyme F430 and the Posttranslational Modification of the Active Site Region of Methyl-Coenzyme M Reductase 323 Steven O. Mansoorabadi, Kaiyuan Zheng and Phong D. Ngo Coenzyme B12 Biosynthesis in Bacteria and Archaea 335 Theodoric A. Mattes, Jorge C. Escalante-Semerena, Evelyne Deery and Martin J. Warren Crosslinked Cys–Tyr Free Radical Redox Cofactor 361 James W. Whittaker Topaquinone Biogenesis and Lysyl Tyrosine Quinone Biogenesis in Cu Amine Oxidases 375 David M. Dooley, Doreen E. Brown and Eric M. Shepard Index 389
Editors Michael K. Johnson, University of Georgia, Athens, GA, USA Robert A. Scott, University of Georgia, Athens, GA, USA
