May We Make the World?

Gene Drives, Malaria, and the Future of Nature

Laurie Zoloth

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English

MIT Press
19 December 2023

Ethics & moral philosophy; Public health & preventive medicine; Medical genetics

Series: Basic Bioethics

"An in-depth look at genetic alteration in the natural world and the oppositions to it, seen through the case study of a gene drive for malaria.

May We Make the World? is an engaging reflection on the history, nature, goal, and meaning of using a new technological idea-CRISPR-based genetic engineering-to alter the genome of the mosquito that carries malaria. This technology, called a ""gene drive,"" can alter the sex ratio in Anopheles gambiae mosquitoes, the key vector for falciparum, the deadliest form of malaria. P. Falciparum kills 400,000 people a year, largely the poorest children in the world among them. In her sobering examination of the issue, Laurie Zoloth considers the leading ethical arguments for and against gene drives, explores the regulatory efforts that have emerged long in advance of the science, and considers the philosophical questions raised by the struggle to eliminate malaria.

The development of a gene drive for malaria will have far-reaching implications for it represents the first use of genetic engineering in the natural world and the first creation of a genetic variant intended to spread in the African wild beyond human control. Drawing on two decades of work, Zoloth brilliantly argues that we can understand the complex moral issues at stake only by carefully reflecting on the science, the nature of the local and global discourse about genetic engineering, and the long history of malaria, which-as it transformed from a worldwide disease to a tropical one-reshaped the world as we know it."

By: Laurie Zoloth
Imprint: MIT Press
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm, Spine: 29mm
Weight: 510g
ISBN: 9780262546980
ISBN 10: 0262546981
Series: Basic Bioethics
Pages: 428
Publication Date: 19 December 2023
Audience: General/trade , ELT Advanced
Format: Paperback
Publisher's Status: Active

Acknowledgments xi Introduction xv 1 The World as We Know It: Malaria and Its History 1 2 The World as It Is Imagined: Gene Drives for Malaria 77 3 The World as We Order It: A Review of Regulation 113 4 The World as We Speak It: Stakeholder Engagement and African Discourses 163 5 The World of Dissent: Listening to Opposition 199 6 The World as We Judge It: Ethical Issues Considered 237 Conclusion: Making the Moral World 299 Notes 323 Index 359

Laurie Zoloth is Margaret E. Burton Professor of Religion and Ethics at the University of Chicago. She has been President of both the American Society for Bioethics and Humanities and the American Academy of Religion and was the Founding Chair of the Howard Hughes Medical Institute Bioethics Advisory Committee. She is the author or coeditor of nine books on bioethics, the humanities, and emerging science, including The Human Embryonic Stem Cell Debate (MIT Press).