Malignant: How Bad Policy and Bad Evidence Harm People with Cancer

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Vinayak K. Prasad (Assistant Professor of Medicine, National Cancer Institute and National Institutes of Health)

Malignant

How Bad Policy and Bad Evidence Harm People with Cancer

Vinayak K. Prasad (Assistant Professor of Medicine, National Cancer Institute and National Institutes of Health)

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English

Johns Hopkins University Press
15 May 2020

Public health & safety law; Oncology; Popular medicine & health

How hype, money, and bias can mislead the public into thinking that many worthless or unproven treatments are effective.

Each week, people read about new and exciting cancer drugs. Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel—but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which

• promote novel cancer therapies long before credible data are available to support such treatment; and • exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.

Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.

This is a book about how the actions of human beings—our policies, our standards of evidence, and our drug regulation—incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,

• more cancer clinical trials should measure outcomes that actually matter to people with cancer; • patients on those trials should look more like actual global citizens; • we need drug regulators to raise, not perpetually lower, the bar for approval; and • we need unbiased patient advocates and experts.

This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer—and how we can avoid repeating the policy and practice mistakes of the past.

By: Vinayak K. Prasad (Assistant Professor of Medicine National Cancer Institute and National Institutes of Health)
Imprint: Johns Hopkins University Press
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm, Spine: 25mm
Weight: 544g
ISBN: 9781421437637
ISBN 10: 1421437635
Pages: 304
Publication Date: 15 May 2020
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Vinayak K. Prasad, MD, MPH is a practicing hematologist-oncologist and internal medicine physician. An associate professor of medicine and public health at Oregon Health & Science University, he is the coauthor of Ending Medical Reversal: Improving Outcomes, Saving Lives.

Reviews for Malignant: How Bad Policy and Bad Evidence Harm People with Cancer

Malignant is punchy and persuasive, and the author is clearly in command of his subject matter. Prasad offers valuable advice on how to keep up with research as well as the appropriate way to analyse clinical trial reports. —Talha K Burki, The Lancet Hematology Aimed at general readers (including patients), oncology trainees and experts in health-care policy, it informs and disturbs throughout. —Andrew Robinson, Nature Patients should ask their oncologist how good the cure is: do I really live longer and better than doing ""nothing""? Let them start by asking whether their doctor has read Prasad's book. —Zurich Weekly News Review [Malignant is] so applicable to the issues of the pandemic . . . Because what we're seeing is a research infrastructure that is not set up to do rapid evaluation, and to be resilient and to respond to a health crisis. —Marty Makary, MD, MPH, MedPage Today