Stefan S. du Plessis, BScHons, Hons B(B&A), MSc, MBA, PhD (Stell), Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa Ashok Agarwal, PhD, HCLD (ABB), ELD (ACE), Center for Reproductive Medicine, Andrology Center, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA Edmund S. Sabanegh, Jr., MD, Department of Urology, Cleveland Clinic, Cleveland, OH, USA